Conventional / global / constitutive KO
●2 Models Available
Pck2 Conditional Knockout, Knockout mouse models
Browse 2 Pck2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Pck2 conditional knockout mouse, Pck2 knockout mouse. Contact us for availability and fast turnaround.
Why model Pck2
Mitochondrial cataplerosis runs through Pck2, the mouse ortholog of human PCK2, which encodes the matrix isoform of phosphoenolpyruvate carboxykinase and catalyzes the GTP-dependent decarboxylation and phosphorylation of oxaloacetate to phosphoenolpyruvate inside the matrix, providing a cataplerotic exit from the TCA cycle that is constitutively expressed rather than hormonally cycled like the cytosolic PCK1 enzyme. Under glucose limitation, this flux routes glutamine-derived oxaloacetate into phosphoenolpyruvate for serine, glycerol and nucleotide biosynthesis, a route repeatedly implicated in tumor survival during nutrient stress and in ATF4-driven integrated stress transcription. The design fork is clear: a conditional null defines where mitochondrial cataplerosis is required without confounding by whole-body metabolic adaptation, while humanization supports inhibitor pharmacology, since selectivity against PCK1 is the central medicinal chemistry problem. Genuine redundancy with cytosolic Pck1 exists in gluconeogenic tissue, so consider compound alleles. Match the allele to isotope tracing flux, tumor growth or systemic glucose handling endpoints.
What Pck2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Pck2 (PCK2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pck2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pck2 allele types
Knockout, conditional, knockin, humanized, and related paths for Pck2 (human PCK2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pck2 catalog models
2 Pck2 lines with QC documentation and technical support. Pck2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pck2 mouse model?
We have 2 Pck2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pck2 Mouse Model Types
A Pck2 knockout mouse has the Pck2 gene permanently inactivated, enabling loss of function studies. A Pck2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pck2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pck2 organized by modification type. Each URL is indexable and matches common search patterns.