Conventional / global / constitutive KO
●3 Models Available
Pck1 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Pck1 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pck1 conditional knockout mouse, Pck1 knockin mouse, Pck1 knockout mouse. Request a quote within 24 hours.
Why model Pck1
Pck1 encodes cytosolic phosphoenolpyruvate carboxykinase, the mouse ortholog of human PCK1, which commits mitochondrially derived oxaloacetate to phosphoenolpyruvate in a GTP-dependent decarboxylation that sets the flux ceiling for hepatic and renal gluconeogenesis and for adipose glyceroneogenesis. Transcription rather than allostery dominates its control: glucagon acting through cAMP and CREB, the glucocorticoid receptor, FOXO1 and PGC-1 alpha drive the promoter, while insulin signaling through AKT suppresses it, making the locus a canonical readout of fasting and insulin resistance. Whole-body deletion is neonatally lethal with massive hepatic steatosis, so albumin-Cre or adipocyte-restricted conditional nulls are required to separate liver from adipose contributions, and promoter-replacement or inducible overexpression alleles test whether transcriptional derepression alone raises glucose output. The mitochondrial paralog Pck2 supplies partial cataplerotic flux but does not rescue cytosolic gluconeogenesis, so compound designs are advisable when quantifying whole-body glucose production.
What Pck1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Pck1 (PCK1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pck1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pck1 allele types
Knockout, conditional, knockin, humanized, and related paths for Pck1 (human PCK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pck1 catalog models
3 Pck1 lines with QC documentation and technical support. Pck1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pck1 mouse model?
We have 3 Pck1 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pck1 Mouse Model Types
A Pck1 knockout mouse has the Pck1 gene permanently inactivated, enabling loss of function studies. A Pck1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pck1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Pck1 knockin models carry a precisely inserted sequence at the Pck1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Pck1 organized by modification type. Each URL is indexable and matches common search patterns.