Conventional / global / constitutive KO
●4 Models Available
Pdgfra Conditional Knockout, Knockin mouse models
Browse 4 Pdgfra mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pdgfra conditional knockout mouse, Pdgfra knockin mouse. Request a quote within 24 hours.
Why model Pdgfra
Pdgfra encodes the mouse ortholog of human PDGFRA, a class III receptor tyrosine kinase that binds PDGF-A, PDGF-C, and PDGF-B as homodimers or as heterodimers with PDGFRB, then autophosphorylates to engage PI3K, phospholipase C gamma, SHP2, and RAS-ERK, directing cranial and cardiac neural crest, oligodendrocyte precursor, and gastrointestinal mesenchymal development. Oncogenic activation takes several distinct forms: activation loop D842V and juxtamembrane mutations in KIT wild-type gastrointestinal stromal tumor, which resist imatinib but respond to avapritinib, FIP1L1-PDGFRA fusions in hypereosinophilic myeloid neoplasms, and amplification in diffuse midline glioma. Germline nulls die in midgestation with craniofacial and cardiac defects, exactly as in the classic Patch deletion, so hotspot knockins should be conditional or inducible, and conditional nulls serve adult mesenchymal and oligodendrocyte questions. The paralog Pdgfrb heterodimerizes and shares ligands, so single-locus deletion can be buffered in perivascular compartments; choose Cre drivers by lineage and read out tumor latency or inhibitor response.
What Pdgfra mouse models are available?
ingenious targeting laboratory offers 4 distinct Pdgfra (PDGFRA) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pdgfra model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pdgfra allele types
Knockout, conditional, knockin, humanized, and related paths for Pdgfra (human PDGFRA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pdgfra catalog models
4 Pdgfra lines with QC documentation and technical support. Pdgfra floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pdgfra-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 200203 - Order
Pdgfra-CreERT2
KnockinCre/Dre Toolbox of Mice
liveKI 225036 - Order
Pdgfra-Dre
KnockinCre/Dre Toolbox of Mice
sperm cryopreservationKI 220193 - Order
Pdgfra-EGFP-CreERT2
KnockinCre/Dre Toolbox of Mice, fluorescent mouse
liveKI 241139
Looking for a Pdgfra mouse model?
We have 4 Pdgfra models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pdgfra Mouse Model Types
A Pdgfra conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pdgfra, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Pdgfra knockin models carry a precisely inserted sequence at the Pdgfra locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Pdgfra organized by modification type. Each URL is indexable and matches common search patterns.