Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM
Pdgfrb Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Pdgfrb mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Pdgfrb conditional knockout mouse, Pdgfrb knockin mouse, Pdgfrb knockout mouse. Contact us for availability and fast turnaround.
Why model Pdgfrb
Signaling in the mural cell compartment depends on Pdgfrb, the mouse ortholog of human PDGFRB, a class III receptor tyrosine kinase activated by PDGF-B and PDGF-D that recruits PI3K, SHP2, and RAS-ERK effectors and is indispensable for pericyte and vascular smooth muscle recruitment to developing endothelium. Human disease spans both directions of dosage: gain-of-function substitutions in infantile myofibromatosis and Kosaki overgrowth syndrome, COL1A1-PDGFB rearrangement in dermatofibrosarcoma protuberans, ETV6-PDGFRB fusions in eosinophilia-associated myeloid neoplasms, and loss-of-function alleles causing primary familial brain calcification with blood brain barrier failure. Germline nulls die perinatally from pericyte deficiency, glomerular defects, and hemorrhage, so conditional deletion with Pdgfrb-cre, Cspg4-cre, or Myh11-cre is required for adult vascular and fibrosis endpoints, while precise activating knockins reproduce myofibromatosis and inhibitor sensitivity. Pdgfra shares ligands and can heterodimerize, so compound alleles clarify mesenchymal redundancy; match allele class to whether the readout is barrier integrity, fibrosis, or tumor response.
What Pdgfrb mouse models are available?
ingenious targeting laboratory offers 4 distinct Pdgfrb (PDGFRB) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pdgfrb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pdgfrb allele types
Knockout, conditional, knockin, humanized, and related paths for Pdgfrb (human PDGFRB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pdgfrb catalog models
4 Pdgfrb lines with QC documentation and technical support. Pdgfrb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pdgfrb-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 3-7 of Pdgfrb gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pdgfrb gene.
Sperm CryopreservedCKO 200204 - Order
Pdgfrb-2A-tdTomato
KIFluorescent Model
The 2A-tdTomato expression cassette was knocked into the Pdgfrb gene stop codon site.
Sperm CryopreservedKI 242616 - Order
Pdgfrb-2A-Cre
KICre/Dre Toolbox
The 2A-Cre expression cassette was knocked into the Pdgfrb gene stop codon site.
Sperm CryopreservedKI 241533 - Order
Pdgfrb-KO
KOKO
The exon 3-7 of Pdgfrb gene was deleted to generate Pdgfrb knockout mouse. There have been reports of deaths caused by genetic modification. For details, click on the MGI ID in the genetic information.
Sperm CryopreservedKO 242464
Looking for a Pdgfrb mouse model?
We have 4 Pdgfrb models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pdgfrb Mouse Model Types
A Pdgfrb knockout mouse has the Pdgfrb gene permanently inactivated, enabling loss of function studies. A Pdgfrb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pdgfrb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Pdgfrb knockin models carry a precisely inserted sequence at the Pdgfrb locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Pdgfrb organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Pdgfrb line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.