Conventional / global / constitutive KO
●5 Models Available
Pdgfrb Conditional Knockout, Knockin, Knockout mouse models
Browse 5 Pdgfrb mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pdgfrb conditional knockout mouse, Pdgfrb knockin mouse, Pdgfrb knockout mouse, Pdgfrb transgenic mouse. Request a quote within 24 hours.
Why model Pdgfrb
Signaling in the mural cell compartment depends on Pdgfrb, the mouse ortholog of human PDGFRB, a class III receptor tyrosine kinase activated by PDGF-B and PDGF-D that recruits PI3K, SHP2, and RAS-ERK effectors and is indispensable for pericyte and vascular smooth muscle recruitment to developing endothelium. Human disease spans both directions of dosage: gain-of-function substitutions in infantile myofibromatosis and Kosaki overgrowth syndrome, COL1A1-PDGFB rearrangement in dermatofibrosarcoma protuberans, ETV6-PDGFRB fusions in eosinophilia-associated myeloid neoplasms, and loss-of-function alleles causing primary familial brain calcification with blood brain barrier failure. Germline nulls die perinatally from pericyte deficiency, glomerular defects, and hemorrhage, so conditional deletion with Pdgfrb-cre, Cspg4-cre, or Myh11-cre is required for adult vascular and fibrosis endpoints, while precise activating knockins reproduce myofibromatosis and inhibitor sensitivity. Pdgfra shares ligands and can heterodimerize, so compound alleles clarify mesenchymal redundancy; match allele class to whether the readout is barrier integrity, fibrosis, or tumor response.
What Pdgfrb mouse models are available?
ingenious targeting laboratory offers 5 distinct Pdgfrb (PDGFRB) catalog mouse models, featuring conditional knockout, standard knockout, knockin, and transgenic. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pdgfrb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pdgfrb allele types
Knockout, conditional, knockin, humanized, and related paths for Pdgfrb (human PDGFRB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pdgfrb catalog models
5 Pdgfrb lines with QC documentation and technical support. Pdgfrb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pdgfrb-Flox
Conditional KnockoutKO/CKO mice, disease model mice
sperm cryopreservationCKO 200204 - Order
Pdgfrb-2A-Cre
KnockinCre/Dre Toolbox of Mice
sperm cryopreservationKI 241533 - Order
Pdgfrb-2A-tdTomato
Knockinfluorescent mouse
liveKI 242616 - Order
Pdgfrb-KO
KnockoutKO/CKO mice
liveKO 242464 - Order
Pdgfrb-CreERT2-Tg
TransgenicCre/Dre Toolbox of Mice, random transgenic mice
liveTG 241616
Looking for a Pdgfrb mouse model?
We have 5 Pdgfrb models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
4
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pdgfrb Mouse Model Types
A Pdgfrb knockout mouse has the Pdgfrb gene permanently inactivated, enabling loss of function studies. A Pdgfrb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pdgfrb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Pdgfrb knockin models carry a precisely inserted sequence at the Pdgfrb locus, useful for reporter, tag, or humanization studies. Pdgfrb transgenic models carry additional copies of the Pdgfrb gene for overexpression studies.
Modifications available
Jump to catalog backed pages for Pdgfrb organized by modification type. Each URL is indexable and matches common search patterns.