Conventional / global / constitutive KO
●2 Models Available
Pdha1 Conditional Knockout, Knockout mouse models
Browse 2 Pdha1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Pdha1 conditional knockout mouse, Pdha1 knockout mouse. Contact us for availability and fast turnaround.
Why model Pdha1
Pdha1, the mouse ortholog of human PDHA1, encodes the E1 alpha subunit of the pyruvate dehydrogenase complex, which pairs with E1 beta in an alpha2beta2 heterotetramer, binds thiamine pyrophosphate, and performs the decarboxylation of pyruvate that commits carbon to acetyl-CoA and the TCA cycle. Regulation runs through three serine residues on this subunit that are phosphorylated by the PDK kinases and reversed by PDP phosphatases, making the protein the direct node where nutrient state gates glycolytic carbon entry into oxidative metabolism. The gene is X-linked, and PDHA1 deficiency is the commonest cause of congenital lactic acidosis, hemizygous in males and mosaic in heterozygous females, an architecture that should shape design: conditional floxed alleles permit tissue-restricted loss without the confound of random X inactivation, while patient-matched knockins retain residual activity for dichloroacetate or ketogenic diet studies. No paralog compensates. Select neuronal or hepatic Cre drivers according to neuropathology or systemic lactate endpoints.
What Pdha1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Pdha1 (PDHA1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pdha1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pdha1 allele types
Knockout, conditional, knockin, humanized, and related paths for Pdha1 (human PDHA1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pdha1 catalog models
2 Pdha1 lines with QC documentation and technical support. Pdha1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pdha1 mouse model?
We have 2 Pdha1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pdha1 Mouse Model Types
A Pdha1 knockout mouse has the Pdha1 gene permanently inactivated, enabling loss of function studies. A Pdha1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pdha1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pdha1 organized by modification type. Each URL is indexable and matches common search patterns.