Conventional / global / constitutive KO
●2 Models Available
Pfkl Conditional Knockout, Knockout mouse models
Browse 2 Pfkl mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Pfkl conditional knockout mouse, Pfkl knockout mouse. Contact us for availability and fast turnaround.
Why model Pfkl
Pfkl is the mouse ortholog of human PFKL and encodes the liver-type subunit of phosphofructokinase 1, the tetrameric enzyme that commits glucose to glycolysis by phosphorylating fructose 6-phosphate to fructose 1,6-bisphosphate, the step under the strongest allosteric control by ATP, citrate, AMP and fructose 2,6-bisphosphate. The L subunit assembles into homotetramers and into hybrid tetramers with the M and P subunits, and the resulting isozyme composition sets tissue-specific sensitivity to those effectors, with the liver-enriched form tuned for gluconeogenic and lipogenic crosstalk. Because the human gene sits on chromosome 21, dosage effects have also been examined in trisomy contexts. Conditional nulls localize where L subunit content limits glycolytic flux, while humanization supports allosteric modulator screening. Since Pfkm and Pfkp form functional tetramers in overlapping tissues, single-locus deletion is frequently buffered and compound conditional alleles are advisable. Match allele class to isotope flux, hepatic glucose output or tumor glycolysis endpoints.
What Pfkl mouse models are available?
ingenious targeting laboratory offers 2 distinct Pfkl (PFKL) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pfkl model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pfkl allele types
Knockout, conditional, knockin, humanized, and related paths for Pfkl (human PFKL). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pfkl catalog models
2 Pfkl lines with QC documentation and technical support. Pfkl floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pfkl mouse model?
We have 2 Pfkl models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pfkl Mouse Model Types
A Pfkl knockout mouse has the Pfkl gene permanently inactivated, enabling loss of function studies. A Pfkl conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pfkl, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pfkl organized by modification type. Each URL is indexable and matches common search patterns.