Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
DEVELOPING · IN PRODUCTION
Pfkm Conditional Knockout, Knockout mouse models
Browse 2 Pfkm mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pfkm conditional knockout mouse, Pfkm knockout mouse. Request a quote within 24 hours.
Why model Pfkm
Skeletal muscle glycolytic capacity rests on Pfkm, the mouse ortholog of human PFKM, which encodes the muscle subunit of phosphofructokinase 1 and dominates the tetramer in that tissue, where it catalyzes the committed, effectively irreversible ATP-dependent phosphorylation of fructose 6-phosphate and integrates AMP, ATP, citrate and fructose 2,6-bisphosphate signals into glycolytic rate. Recessive loss causes Tarui disease, glycogen storage disease type VII, in which exercise intolerance, cramps, myoglobinuria and compensated hemolysis follow from blocked muscle glycolysis, with the erythrocyte phenotype partial rather than complete because red cells contain M and L hybrid tetramers. Model design follows that tissue logic: a germline or muscle-restricted conditional null reproduces the metabolic myopathy, while patient-matched missense or splice knockins model residual activity and milder late-onset forms. Redundancy with Pfkl and Pfkp is real outside muscle. Choose the allele by endpoint, whether exercise challenge, glycogen accumulation, phosphorus magnetic resonance spectroscopy or hemolytic indices are the primary measures.
What Pfkm mouse models are available?
ingenious targeting laboratory offers 2 distinct Pfkm (PFKM) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pfkm model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pfkm allele types
Knockout, conditional, knockin, humanized, and related paths for Pfkm (human PFKM). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pfkm catalog models
2 Pfkm lines with QC documentation and technical support. Pfkm floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pfkm-Flox
CKOCKO
These mice carry loxP sites flanking exon3-4 of Pfkm gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pfkm gene.
In DevelopmentCKO 262882 - Order
Pfkm-KO
KOKO, Disease Model
Exon 3 of Pfkm gene was deleted to generate Pfkm knockout mice.
In production — inquireKO 201321
Looking for a Pfkm mouse model?
We have 2 Pfkm models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pfkm Mouse Model Types
A Pfkm knockout mouse has the Pfkm gene permanently inactivated, enabling loss of function studies. A Pfkm conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pfkm, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pfkm organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Pfkm line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.