Conventional / global / constitutive KO
●2 Models Available
Pik3cb Conditional Knockout, Knockout mouse models
Browse 2 Pik3cb mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Pik3cb conditional knockout mouse, Pik3cb knockout mouse. Contact us for availability and fast turnaround.
Why model Pik3cb
Encoding p110 beta, Pik3cb is the ortholog of human PIK3CB and is unique among class IA catalytic subunits in receiving direct input from G protein coupled receptors through G beta gamma and from RAC1 and CDC42, in addition to canonical p85 mediated recruitment by phosphotyrosine. That wiring makes it the principal PIP3 source in PTEN-deficient prostate and other tumors and a driver of integrin dependent platelet activation and arterial thrombosis. Germline deletion is embryonic lethal, so conditional nulls are the practical tool, and a kinase-dead knockin is especially informative because p110 beta retains kinase-independent scaffolding roles in clathrin-mediated endocytosis and nuclear DNA replication that a null would conflate with catalytic loss. Given the reciprocal dependence between p110 alpha and p110 beta after isoform-selective inhibition, endpoint dictates design: pair conditional Pik3cb loss with Pten deletion for tumor latency, and choose kinase-dead alleles when the question is catalysis versus scaffold.
What Pik3cb mouse models are available?
ingenious targeting laboratory offers 2 distinct Pik3cb (PIK3CB) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pik3cb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pik3cb allele types
Knockout, conditional, knockin, humanized, and related paths for Pik3cb (human PIK3CB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pik3cb catalog models
2 Pik3cb lines with QC documentation and technical support. Pik3cb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pik3cb mouse model?
We have 2 Pik3cb models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pik3cb Mouse Model Types
A Pik3cb knockout mouse has the Pik3cb gene permanently inactivated, enabling loss of function studies. A Pik3cb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pik3cb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pik3cb organized by modification type. Each URL is indexable and matches common search patterns.