Conventional / global / constitutive KO
●3 Models Available
Pik3ca Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Pik3ca mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pik3ca conditional knockout mouse, Pik3ca knockin mouse, Pik3ca knockout mouse. Request a quote within 24 hours.
Why model Pik3ca
Pik3ca, the mouse ortholog of PIK3CA, encodes p110 alpha, the class IA PI3K catalytic subunit that heterodimerizes with p85 regulatory subunits and phosphorylates PIP2 to PIP3 downstream of receptor tyrosine kinases and RAS, nucleating PDPK1 and AKT recruitment at the membrane. Oncogenic substitutions cluster in two structural classes with distinct mechanisms: helical domain changes E542K and E545K relieve the p85 nSH2 inhibitory contact, whereas the kinase domain change H1047R alters the membrane-binding interface, and the same alleles cause PIK3CA-related overgrowth spectrum when mosaic. Cre-activated latent knockins such as a lox-stop-lox H1047R allele are therefore standard for modeling dose and timing of activation, kinase-dead knockins isolate lipid kinase output from scaffolding, and conditional nulls test tissue dependence, since germline deletion is embryonic lethal at midgestation. Because p110 beta sustains PIP3 in some lineages, interpret isoform-selective inhibitor studies against compound Pik3ca and Pik3cb genetics.
What Pik3ca mouse models are available?
ingenious targeting laboratory offers 3 distinct Pik3ca (PIK3CA) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pik3ca model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pik3ca allele types
Knockout, conditional, knockin, humanized, and related paths for Pik3ca (human PIK3CA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pik3ca catalog models
3 Pik3ca lines with QC documentation and technical support. Pik3ca floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pik3ca mouse model?
We have 3 Pik3ca models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pik3ca Mouse Model Types
A Pik3ca knockout mouse has the Pik3ca gene permanently inactivated, enabling loss of function studies. A Pik3ca conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pik3ca, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Pik3ca knockin models carry a precisely inserted sequence at the Pik3ca locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Pik3ca organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Pik3ca.