Conventional / global / constitutive KO
●3 Models Available
Pkm Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 3 Pkm mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pkm conditional knockout mouse, Pkm knockout mouse, Pkm xenograft-applicable mouse. Request a quote within 24 hours.
Why model Pkm
Pkm, the mouse ortholog of human PKM, encodes pyruvate kinase M and is regulated principally by mutually exclusive splicing of exon 9 versus exon 10, controlled by PTBP1 and by hnRNPA1 and hnRNPA2, yielding either the constitutively active PKM1 tetramer typical of differentiated tissue or PKM2, whose tetramer to dimer equilibrium responds to fructose 1,6-bisphosphate, serine, phosphotyrosine peptides and acetylation. The low-activity PKM2 dimer throttles the terminal glycolytic step, backing upstream intermediates into biosynthetic branches and underpinning the Warburg phenotype, with additional nuclear functions reported. Consequently, isoform-selective engineering matters more than deletion: exon-specific alleles that force PKM1 or PKM2 expression test the splicing hypothesis directly, while conditional nulls address whether the locus is required at all in a given lineage. The Pklr paralog covers liver and erythroid tissue only. Match the allele to lactate flux, biosynthetic tracing or tumor initiation endpoints with tissue-matched Cre drivers.
What Pkm mouse models are available?
ingenious targeting laboratory offers 3 distinct Pkm (PKM) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Pkm model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pkm allele types
Knockout, conditional, knockin, humanized, and related paths for Pkm (human PKM). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pkm catalog models
3 Pkm lines with QC documentation and technical support. Pkm floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pkm mouse model?
We have 3 Pkm models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pkm Mouse Model Types
A Pkm knockout mouse has the Pkm gene permanently inactivated, enabling loss of function studies. A Pkm conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pkm, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pkm organized by modification type. Each URL is indexable and matches common search patterns.