Conventional / global / constitutive KO
●2 Models Available
Pla2g6 Conditional Knockout, Knockout mouse models
Browse 2 Pla2g6 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pla2g6 conditional knockout mouse, Pla2g6 knockout mouse. Request a quote within 24 hours.
Why model Pla2g6
Membrane phospholipid remodeling depends on Pla2g6, the mouse ortholog of human PLA2G6, encoding calcium-independent phospholipase A2 beta, an ankyrin repeat containing enzyme with a canonical GXSXG lipase motif that hydrolyzes the sn-2 acyl chain of glycerophospholipids to release fatty acids and lysophospholipids. This activity governs membrane fatty acid remodeling, mitochondrial and ER membrane integrity, store-operated calcium signaling, and arachidonate supply. Recessive mutations cause infantile neuroaxonal dystrophy, atypical neuroaxonal dystrophy, and PARK14 dystonia-parkinsonism, with axonal spheroids, tubulovesicular membrane accumulation, and variable brain iron deposition. Usefully, Pla2g6 knockout and patient-type missense knockin mice do develop progressive spheroid pathology and motor decline, making constitutive null a legitimate starting allele, while catalytically dead knockins separate loss of hydrolase activity from dominant-negative effects. Conditional alleles crossed to neuronal or dopaminergic Cre lines are preferable when regional axonal degeneration rather than systemic lipid change is the endpoint.
What Pla2g6 mouse models are available?
ingenious targeting laboratory offers 2 distinct Pla2g6 (PLA2G6) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pla2g6 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pla2g6 allele types
Knockout, conditional, knockin, humanized, and related paths for Pla2g6 (human PLA2G6). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pla2g6 catalog models
2 Pla2g6 lines with QC documentation and technical support. Pla2g6 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pla2g6 mouse model?
We have 2 Pla2g6 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pla2g6 Mouse Model Types
A Pla2g6 knockout mouse has the Pla2g6 gene permanently inactivated, enabling loss of function studies. A Pla2g6 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pla2g6, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pla2g6 organized by modification type. Each URL is indexable and matches common search patterns.