Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM · IN PRODUCTION
Plau Conditional Knockout, Knockout mouse models
Browse 2 Plau mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Plau conditional knockout mouse, Plau knockout mouse. Request a quote within 24 hours.
Why model Plau
Encoding urokinase-type plasminogen activator, Plau is the mouse ortholog of human PLAU and produces a single-chain zymogen that binds its GPI-anchored receptor uPAR (Plaur) through an N-terminal growth factor domain, is activated by plasmin or cathepsin cleavage, and then generates plasmin at the cell surface rather than in the fluid phase. This pericellular proteolysis drives matrix degradation, latent TGF-beta and pro-MMP activation, macrophage and smooth muscle migration, and integrin plus vitronectin dependent signaling that persists even when catalysis is blocked. Consequently a conditional null tests requirement in myeloid, endothelial, or tumor compartments, an active-site knockin separates proteolysis from uPAR occupancy, and humanization of the growth factor domain is necessary for antibodies or ATF fusions that ignore mouse protein. Plat and plasma kallikrein compensate in the fluid phase, so pair Plau alleles with invasion, fibrosis, or fibrinolysis endpoints and a validated lineage Cre.
What Plau mouse models are available?
ingenious targeting laboratory offers 2 distinct Plau (PLAU) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Plau model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Plau allele types
Knockout, conditional, knockin, humanized, and related paths for Plau (human PLAU). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Plau catalog models
2 Plau lines with QC documentation and technical support. Plau floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Plau-Flox
CKOCKO
These mice carry loxP sites flanking exon 3-4 of Plau gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Plau gene.
In production — inquireCKO 253996 - Order
Plau-KO
KOKO, Disease Model
Exon 3-4 of Plau gene was deleted to generate Plau knockout mice.
Sperm CryopreservedKO 190855
Looking for a Plau mouse model?
We have 2 Plau models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Plau Mouse Model Types
A Plau knockout mouse has the Plau gene permanently inactivated, enabling loss of function studies. A Plau conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Plau, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Plau organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Plau line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.