Conventional / global / constitutive KO
●2 Models Available
Ppargc1a Conditional Knockout, Knockout mouse models
Browse 2 Ppargc1a mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ppargc1a conditional knockout mouse, Ppargc1a knockout mouse. Request a quote within 24 hours.
Why model Ppargc1a
PGC-1 alpha, encoded by Ppargc1a and orthologous to human PPARGC1A, is not a DNA-binding factor but an inducible coactivator that uses N-terminal LXXLL motifs to dock NRF1, ERR alpha, PPARs, MEF2C and nuclear hormone receptors, then recruits SRC-1, CBP and p300 plus the mediator complex to drive mitochondrial biogenesis through TFAM and oxidative gene programs. Activity is set post-translationally by AMPK phosphorylation and SIRT1-dependent deacetylation, integrating energy charge with NAD+ status, and by alternative promoter usage that yields exercise-induced amino-terminal isoforms with distinct stability. Because germline nulls are viable but show hepatic, cardiac and behavioral abnormalities, the informative designs are tissue-restricted conditional nulls in muscle, heart or brown fat and inducible overexpression alleles testing sufficiency for fiber-type switching. Ppargc1b and Pprc1 overlap partially, and combined muscle deletion produces far stronger mitochondrial phenotypes, so plan compound genetics when quantifying respiratory capacity.
What Ppargc1a mouse models are available?
ingenious targeting laboratory offers 2 distinct Ppargc1a (PPARGC1A) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ppargc1a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ppargc1a allele types
Knockout, conditional, knockin, humanized, and related paths for Ppargc1a (human PPARGC1A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ppargc1a catalog models
2 Ppargc1a lines with QC documentation and technical support. Ppargc1a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ppargc1a mouse model?
We have 2 Ppargc1a models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ppargc1a Mouse Model Types
A Ppargc1a knockout mouse has the Ppargc1a gene permanently inactivated, enabling loss of function studies. A Ppargc1a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ppargc1a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ppargc1a organized by modification type. Each URL is indexable and matches common search patterns.