Conventional / global / constitutive KO
●2 Models Available
Pparg Conditional Knockout, Xenograft-Applicable mouse models
Browse 2 Pparg mouse models including conditional knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pparg conditional knockout mouse, Pparg xenograft-applicable mouse. Request a quote within 24 hours.
Why model Pparg
Adipocyte identity depends on Pparg, the mouse ortholog of PPARG, a ligand-activated nuclear receptor that heterodimerizes with RXR alpha and occupies PPRE elements through tandem zinc fingers, while its ligand-binding domain accommodates fatty acid derivatives and thiazolidinediones and exchanges NCoR corepressor for coactivators upon agonist binding. Insulin sensitization additionally depends on blocking CDK5 and ERK phosphorylation of Ser273, which reprograms rather than simply activates the receptor. The PPARG2 isoform, carrying an extra amino-terminal segment from an upstream promoter, is adipose-restricted, so isoform-specific alleles ask different questions than pan-locus deletion. Germline null is embryonic lethal from placental vascular failure, making adipocyte, macrophage or intestinal conditional nulls mandatory, while dominant-negative knockins such as P467L reproduce familial partial lipodystrophy and Ser273 phospho-dead alleles isolate the antidiabetic mechanism. Ppara and Ppard bind overlapping ligands but cannot restore adipogenesis, so compensation is confined to lipid oxidation endpoints.
What Pparg mouse models are available?
ingenious targeting laboratory offers 2 distinct Pparg (PPARG) catalog mouse models, featuring conditional knockout and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Pparg model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pparg allele types
Knockout, conditional, knockin, humanized, and related paths for Pparg (human PPARG). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pparg catalog models
2 Pparg lines with QC documentation and technical support. Pparg floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pparg mouse model?
We have 2 Pparg models in stock — including Conditional Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pparg Mouse Model Types
A Pparg conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pparg, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pparg organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Pparg.