Conventional / global / constitutive KO
●2 Models Available
Prkaa2 Conditional Knockout, Knockout mouse models
Browse 2 Prkaa2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Prkaa2 conditional knockout mouse, Prkaa2 knockout mouse. Request a quote within 24 hours.
Why model Prkaa2
Skeletal muscle, liver and the nuclear compartment rely disproportionately on AMPK alpha2, the catalytic subunit encoded by Prkaa2 and orthologous to human PRKAA2, which shares the Thr172 activation loop and LKB1 and CaMKK2 inputs with alpha1 but carries a nuclear localization signal and a distinct autoinhibitory region that tune its response to contraction and fasting. Constitutive nulls are viable yet glucose intolerant with reduced exercise-stimulated glucose uptake and blunted AICAR responses, evidence that alpha1 covers part but not all of the requirement. Design accordingly: muscle or hepatocyte conditional nulls isolate tissue-autonomous metabolic control, a dominant-negative K45R allele interrogates acute pathway suppression, and truncated constitutively active knockins test sufficiency for mitochondrial biogenesis. Because alpha1 and alpha2 heterotrimers differ mainly in subcellular distribution rather than substrate preference, quantify residual Thr172 and ACC phosphorylation before assigning any phenotype to Prkaa2 alone.
What Prkaa2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Prkaa2 (PRKAA2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Prkaa2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Prkaa2 allele types
Knockout, conditional, knockin, humanized, and related paths for Prkaa2 (human PRKAA2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Prkaa2 catalog models
2 Prkaa2 lines with QC documentation and technical support. Prkaa2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Prkaa2 mouse model?
We have 2 Prkaa2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Prkaa2 Mouse Model Types
A Prkaa2 knockout mouse has the Prkaa2 gene permanently inactivated, enabling loss of function studies. A Prkaa2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Prkaa2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Prkaa2 organized by modification type. Each URL is indexable and matches common search patterns.