Conventional / global / constitutive KO
●2 Models Available
Rela Conditional Knockout, Knockout mouse models
Browse 2 Rela mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Rela conditional knockout mouse, Rela knockout mouse. Request a quote within 24 hours.
Why model Rela
Rela encodes p65, the ortholog of human RELA and the principal transactivating subunit of canonical NF-kappaB, which dimerizes with p50 through its Rel homology domain, is retained in the cytoplasm by IkappaB alpha, and enters the nucleus after IKK beta phosphorylates IkappaB alpha and triggers its ubiquitin-dependent degradation, with Ser536 and Ser276 phosphorylation and p300 acetylation tuning output at kappaB elements. Germline deletion is embryonic lethal at midgestation from TNF-driven hepatocyte apoptosis, a lethality rescued by concurrent Tnfrsf1a deficiency, which is a useful genetic maneuver but shifts the inflammatory baseline. Conditional nulls with hepatocyte, myeloid or intestinal epithelial Cre drivers are therefore standard for inflammation and tumor promotion endpoints, while phospho-site or transactivation domain knockins separate nuclear entry from cofactor recruitment. Rel and Relb do not substitute for p65 in canonical target induction, so compensation is limited and single-locus phenotypes are usually interpretable.
What Rela mouse models are available?
ingenious targeting laboratory offers 2 distinct Rela (RELA) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Rela model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Rela allele types
Knockout, conditional, knockin, humanized, and related paths for Rela (human RELA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Rela (RELA) from ITL supported projects.
- Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic NeurodegenerationJiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Malampati S, Whyte L, Basavarajappa BS, Shivakumar S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA. (2025). . J Neurosci 29(45): e2331242025.
- NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promotersNavarro HI, Daly AE, Rodriguez B, Wu S, Ngo KA, Fraser A, Schiffman A, Liu Y, Smale ST, Chia JJ, Hoffmann A. (2025). Cell Discov 11(1): 13.
- EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory.Barth K, Vasić V, McDonald B, Heinig N, Wagner MC, Schumann U, Röhlecke C, Bicker F, Schumann L, Radyushkin K, Baumgart J, Tenzer S, Zipp F, Meinhardt M, Alitalo K, Tegeder I, Schmidt MHH. (2023). Cell Mol Life Sci 80(2): 54
- Novel idiopathic DCM-related SCN5A variants localised in DI-S4 predispose electrical disorders by reducing peak sodium current densityShen C, Xu L, Han S, Dong Z, Zhao X, Wang S, Qian S, Li B, Ma X, Wang P, Zhu H, Zou Y, Fan Z, Ge J, Sun A. (2017). J Med Genet 54(11): 762-770
- Decreased cohesin in the brain leads to defective synapse development and anxiety-related behaviorFujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T. (2017). J Exp Med 214(5): 1431-1452
Looking for a Rela mouse model?
We have 2 Rela models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Rela Mouse Model Types
A Rela knockout mouse has the Rela gene permanently inactivated, enabling loss of function studies. A Rela conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rela, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Rela organized by modification type. Each URL is indexable and matches common search patterns.