Conventional / global / constitutive KO
●2 Models Available
S100a8 Conditional Knockout, Knockout mouse models
Browse 2 S100a8 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as S100a8 conditional knockout mouse, S100a8 knockout mouse. Request a quote within 24 hours.
Why model S100a8
S100a8, the mouse ortholog of human S100A8, encodes MRP8 (calgranulin A), a small EF-hand protein that heterodimerizes obligately with S100A9 to form calprotectin, the dominant cytosolic cargo of neutrophils and inflammatory monocytes. Released calprotectin chelates zinc and manganese to starve bacteria and fungi, engages TLR4 and RAGE to amplify NF-kB driven cytokine output and endothelial activation, and promotes myeloid-derived suppressor cell accumulation in tumors, while intracellularly the complex supports NADPH oxidase assembly and tubulin dynamics. Notably, germline S100a8 disruption has been reported as early embryonic lethal with resorption, whereas S100a9 nulls are viable and lack detectable S100A8 protein because the partner is unstable alone, so conditional or myeloid-restricted deletion is the safer design. Zinc-binding or dimer-interface knockins separate nutritional immunity from receptor signaling. Fit alleles to bacterial clearance, arthritis severity, or calprotectin biomarker endpoints.
What S100a8 mouse models are available?
ingenious targeting laboratory offers 2 distinct S100a8 (S100A8) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
S100a8 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
S100a8 allele types
Knockout, conditional, knockin, humanized, and related paths for S100a8 (human S100A8). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available S100a8 catalog models
2 S100a8 lines with QC documentation and technical support. S100a8 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a S100a8 mouse model?
We have 2 S100a8 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About S100a8 Mouse Model Types
A S100a8 knockout mouse has the S100a8 gene permanently inactivated, enabling loss of function studies. A S100a8 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of S100a8, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for S100a8 organized by modification type. Each URL is indexable and matches common search patterns.