Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM
S100a8 Conditional Knockout, Knockout mouse models
Browse 2 S100a8 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as S100a8 conditional knockout mouse, S100a8 knockout mouse. Contact us for availability and fast turnaround.
Why model S100a8
S100a8, the mouse ortholog of human S100A8, encodes MRP8 (calgranulin A), a small EF-hand protein that heterodimerizes obligately with S100A9 to form calprotectin, the dominant cytosolic cargo of neutrophils and inflammatory monocytes. Released calprotectin chelates zinc and manganese to starve bacteria and fungi, engages TLR4 and RAGE to amplify NF-kB driven cytokine output and endothelial activation, and promotes myeloid-derived suppressor cell accumulation in tumors, while intracellularly the complex supports NADPH oxidase assembly and tubulin dynamics. Notably, germline S100a8 disruption has been reported as early embryonic lethal with resorption, whereas S100a9 nulls are viable and lack detectable S100A8 protein because the partner is unstable alone, so conditional or myeloid-restricted deletion is the safer design. Zinc-binding or dimer-interface knockins separate nutritional immunity from receptor signaling. Fit alleles to bacterial clearance, arthritis severity, or calprotectin biomarker endpoints.
What S100a8 mouse models are available?
ingenious targeting laboratory offers 2 distinct S100a8 (S100A8) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
S100a8 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
S100a8 allele types
Knockout, conditional, knockin, humanized, and related paths for S100a8 (human S100A8). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available S100a8 catalog models
2 S100a8 lines with QC documentation and technical support. S100a8 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
S100a8-Flox
CKOCKO
These mice carry loxP sites flanking exon 2-3 of S100a8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of S100a8 gene.
Sperm CryopreservedCKO 226343 - Order
S100a8-KO
KOKO
The exon 2-3 of S100a8 gene was deleted to generate S100a8 knockout mouse.
Sperm CryopreservedKO 233472
Looking for a S100a8 mouse model?
We have 2 S100a8 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About S100a8 Mouse Model Types
A S100a8 knockout mouse has the S100a8 gene permanently inactivated, enabling loss of function studies. A S100a8 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of S100a8, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for S100a8 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the S100a8 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.