Conventional / global / constitutive KO
●3 Models Available
S100a9 Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 3 S100a9 mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as S100a9 conditional knockout mouse, S100a9 knockout mouse, S100a9 xenograft-applicable mouse. Request a quote within 24 hours.
Why model S100a9
Encoding MRP14 (calgranulin B), S100a9 is the mouse ortholog of human S100A9 and pairs with S100A8 through a hydrophobic interface to build the calprotectin heterodimer, then assembles into calcium-dependent tetramers that are the receptor-active species for TLR4 and RAGE. The protein carries a C-terminal extension with an additional metal site and a phosphorylation-regulated segment, and it directs the complex to membranes and to the NADPH oxidase during neutrophil activation, while extracellular tetramers drive chemotaxis, beta 2 integrin affinity maturation, and metal sequestration that restricts microbial growth. Nulls are viable but lose S100A8 protein as well, which confounds subunit-specific conclusions and argues for tetramerization-deficient or metal-site knockins alongside myeloid conditional alleles. Because mice lack S100a12, calgranulin biology cannot be fully reconstructed without human transgenes. Match the allele to endpoints such as sepsis mortality, autoimmune arthritis, or tumor myeloid suppression.
What S100a9 mouse models are available?
ingenious targeting laboratory offers 3 distinct S100a9 (S100A9) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
S100a9 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
S100a9 allele types
Knockout, conditional, knockin, humanized, and related paths for S100a9 (human S100A9). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available S100a9 catalog models
3 S100a9 lines with QC documentation and technical support. S100a9 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a S100a9 mouse model?
We have 3 S100a9 models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About S100a9 Mouse Model Types
A S100a9 knockout mouse has the S100a9 gene permanently inactivated, enabling loss of function studies. A S100a9 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of S100a9, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for S100a9 organized by modification type. Each URL is indexable and matches common search patterns.