Conventional / global / constitutive KO
●2 Models Available
Scn9a Conditional Knockout, Knockout mouse models
Browse 2 Scn9a mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Scn9a conditional knockout mouse, Scn9a knockout mouse. Contact us for availability and fast turnaround.
Why model Scn9a
Nociceptor threshold setting is the province of Scn9a, the mouse ortholog of human SCN9A, encoding Nav1.7, a tetrodotoxin-sensitive alpha subunit expressed in dorsal root and trigeminal ganglion neurons and sympathetic neurons, where slow closed-state inactivation lets it amplify subthreshold depolarizations and act as a threshold channel. Human genetics is unusually decisive: biallelic loss of function produces congenital insensitivity to pain with anosmia, while gain of function missense alleles cause inherited erythromelalgia (hyperpolarized activation) and paroxysmal extreme pain disorder (impaired fast inactivation). Global Scn9a nulls die shortly after birth, so conditional alleles crossed to Advillin-Cre, Nav1.8-Cre, or Wnt1-Cre are standard for adult pain phenotyping, while patient knockins such as I848T model gain of function pharmacology and humanized alleles enable selective blocker and antibody testing. Compensation from Scn10a and Scn11a within the same neurons is real, so match allele class to behavioral or electrophysiological endpoints accordingly.
What Scn9a mouse models are available?
ingenious targeting laboratory offers 2 distinct Scn9a (SCN9A) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Scn9a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Scn9a allele types
Knockout, conditional, knockin, humanized, and related paths for Scn9a (human SCN9A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Scn9a catalog models
2 Scn9a lines with QC documentation and technical support. Scn9a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Scn9a mouse model?
We have 2 Scn9a models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Scn9a Mouse Model Types
A Scn9a knockout mouse has the Scn9a gene permanently inactivated, enabling loss of function studies. A Scn9a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Scn9a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Scn9a organized by modification type. Each URL is indexable and matches common search patterns.