Conventional / global / constitutive KO
●2 Models Available
Scn1a Conditional Knockout, Knockin mouse models
Browse 2 Scn1a mouse models including conditional knockout, knockin variants from ingenious targeting laboratory. Available as Scn1a conditional knockout mouse, Scn1a knockin mouse. Contact us for availability and fast turnaround.
Why model Scn1a
Interneuron excitability in mouse depends on Scn1a, ortholog of human SCN1A, encoding the Nav1.1 pore-forming alpha subunit assembled from four homologous domains, each contributing six transmembrane segments with an S4 voltage sensor and a re-entrant P loop, plus the DIII to DIV linker carrying the IFM fast inactivation particle. Nav1.1 is enriched in the axon initial segment of parvalbumin and somatostatin interneurons, so haploinsufficiency preferentially silences inhibition and produces the disinhibition seen in Dravet syndrome, while milder missense alleles cause GEFS+ and specific gain of function variants cause familial hemiplegic migraine 3. Allele class maps precisely onto question: heterozygous conditional null models Dravet dosage, patient knockins such as R1648H or A1783V test channel biophysics, and humanized alleles enable antisense or gene therapy testing. Homozygous nulls die by roughly postnatal day 15 and seizure severity is strongly background dependent, so fix strain and choose interneuron-restricted Cre carefully.
What Scn1a mouse models are available?
ingenious targeting laboratory offers 2 distinct Scn1a (SCN1A) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Scn1a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Scn1a allele types
Knockout, conditional, knockin, humanized, and related paths for Scn1a (human SCN1A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Scn1a catalog models
2 Scn1a lines with QC documentation and technical support. Scn1a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Scn1a mouse model?
We have 2 Scn1a models available — including Conditional Knockout, Knockin types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Scn1a Mouse Model Types
A Scn1a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Scn1a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Scn1a knockin models carry a precisely inserted sequence at the Scn1a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Scn1a organized by modification type. Each URL is indexable and matches common search patterns.