Conventional / global / constitutive KO
●2 Models Available
Sdha Conditional Knockout, Knockout mouse models
Browse 2 Sdha mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Sdha conditional knockout mouse, Sdha knockout mouse. Contact us for availability and fast turnaround.
Why model Sdha
Sdha is the mouse ortholog of human SDHA and encodes the flavoprotein catalytic subunit of succinate dehydrogenase, the only enzyme shared by the TCA cycle and the electron transport chain, which oxidizes succinate to fumarate using a covalently bound FAD attached through a histidyl linkage installed by the SDHAF2 flavinylation factor. Electrons pass from FAD into the iron-sulfur relay of SDHB and onward to ubiquinone at the membrane anchor formed by SDHC and SDHD. Biallelic hypomorphic alleles cause Leigh syndrome and cardiomyopathy, whereas heterozygous germline loss with a somatic second hit predisposes to paraganglioma, gastrointestinal stromal tumor and renal tumors through succinate accumulation that inhibits alpha-ketoglutarate-dependent dioxygenases. Design accordingly: patient-matched knockins model the recessive bioenergetic disease, while conditional nulls in chromaffin or neural crest lineages model the tumor suppressor arm. No paralog substitutes. Match allele to succinate to fumarate ratio, DNA hypermethylation or pseudohypoxic HIF signaling endpoints.
What Sdha mouse models are available?
ingenious targeting laboratory offers 2 distinct Sdha (SDHA) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Sdha model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Sdha allele types
Knockout, conditional, knockin, humanized, and related paths for Sdha (human SDHA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Sdha catalog models
2 Sdha lines with QC documentation and technical support. Sdha floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Sdha mouse model?
We have 2 Sdha models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Sdha Mouse Model Types
A Sdha knockout mouse has the Sdha gene permanently inactivated, enabling loss of function studies. A Sdha conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sdha, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Sdha organized by modification type. Each URL is indexable and matches common search patterns.