Conventional / global / constitutive KO
●2 Models Available
Sdhb Conditional Knockout, Knockout mouse models
Browse 2 Sdhb mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Sdhb conditional knockout mouse, Sdhb knockout mouse. Contact us for availability and fast turnaround.
Why model Sdhb
Sdhb, the mouse ortholog of human SDHB, encodes the iron-sulfur subunit of complex II, carrying the [2Fe-2S], [4Fe-4S] and [3Fe-4S] clusters that form the electron relay from the FAD of SDHA to the ubiquinone site created by SDHC and SDHD. Germline loss-of-function alleles combined with somatic loss of the wild-type copy define one of the strongest tumor suppressor mechanisms in paraganglioma, pheochromocytoma, gastrointestinal stromal tumor and renal cell carcinoma, and carriers show a notably high rate of metastatic disease. The mechanism is metabolite driven: accumulated succinate competitively inhibits alpha-ketoglutarate-dependent dioxygenases including TET demethylases, KDM histone demethylases and PHD prolyl hydroxylases, producing a hypermethylator phenotype and pseudohypoxic HIF stabilization. Conditional nulls in chromaffin or neural crest lineages are therefore the tumor-relevant design, while knockins model hypomorphic bioenergetic disease. No paralog substitutes. Match the allele to methylome, HIF target or tumor latency endpoints and validate lineage-specific Cre expression.
What Sdhb mouse models are available?
ingenious targeting laboratory offers 2 distinct Sdhb (SDHB) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Sdhb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Sdhb allele types
Knockout, conditional, knockin, humanized, and related paths for Sdhb (human SDHB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Sdhb catalog models
2 Sdhb lines with QC documentation and technical support. Sdhb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Sdhb mouse model?
We have 2 Sdhb models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Sdhb Mouse Model Types
A Sdhb knockout mouse has the Sdhb gene permanently inactivated, enabling loss of function studies. A Sdhb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sdhb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Sdhb organized by modification type. Each URL is indexable and matches common search patterns.