Conventional / global / constitutive KO
●3 Models Available
Serpinf1 Conditional Knockout, Knockout mouse models
Browse 3 Serpinf1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Serpinf1 conditional knockout mouse, Serpinf1 knockout mouse. Request a quote within 24 hours.
Why model Serpinf1
Serpinf1, the mouse ortholog of human SERPINF1, encodes pigment epithelium derived factor, a non-inhibitory serpin whose reactive center loop is proteolytically nonfunctional and which instead uses an asymmetric charge distribution to bind collagen I and glycosaminoglycans on one face and laminin receptor plus PNPLA2 on the other. Through those interactions PEDF acts as a potent endogenous antiangiogenic and neurotrophic factor, inducing endothelial FAS dependent apoptosis and dampening VEGF signaling, while in bone it is required for osteoid mineralization, so recessive human loss of function causes osteogenesis imperfecta type VI with normal collagen but defective matrix mineralization. Nulls are viable and reproduce low bone mass with increased retinal and pancreatic vascularity, making germline deletion useful, while receptor-binding-domain knockins separate antiangiogenic from lipase-modulating and neurotrophic activities and conditional alleles isolate retinal pigment epithelium or osteoblast sources. Anchor the allele to choroidal neovascularization, bone mineral density, or photoreceptor survival endpoints.
What Serpinf1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Serpinf1 (SERPINF1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Serpinf1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Serpinf1 allele types
Knockout, conditional, knockin, humanized, and related paths for Serpinf1 (human SERPINF1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Serpinf1 catalog models
3 Serpinf1 lines with QC documentation and technical support. Serpinf1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Serpinf1 mouse model?
We have 3 Serpinf1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Serpinf1 Mouse Model Types
A Serpinf1 knockout mouse has the Serpinf1 gene permanently inactivated, enabling loss of function studies. A Serpinf1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Serpinf1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Serpinf1 organized by modification type. Each URL is indexable and matches common search patterns.