Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
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Setx Knockin, Knockout mouse models
Browse 2 Setx mouse models including knockin, knockout variants from ingenious targeting laboratory. Available as Setx knockin mouse, Setx knockout mouse. Contact us for availability and fast turnaround.
Why model Setx
Co-transcriptional R-loop resolution requires Setx, the mouse ortholog of human SETX, encoding senataxin, a large superfamily 1 helicase with a C-terminal DNA and RNA helicase domain and an N-terminal protein interaction region contacting RNA polymerase II, the RNA exosome, and DNA damage response factors. Senataxin unwinds RNA:DNA hybrids at transcription termination sites and at collisions between transcription and replication, limiting genome instability and supporting antisense transcript degradation and meiotic sex chromosome inactivation. Disease logic splits cleanly: recessive loss of function causes ataxia with oculomotor apraxia type 2, while dominant L389S and R2136H alleles cause juvenile ALS4 through an apparent gain or change of function. Allele design must therefore separate conditional null from dominant point knockins, since these model different diseases. Note that Setx null males are sterile with meiotic arrest, so conditional deletion with a neuronal Cre is preferable when motor neuron or cerebellar endpoints are the focus.
What Setx mouse models are available?
ingenious targeting laboratory offers 2 distinct Setx (SETX) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Setx model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Setx allele types
Knockout, conditional, knockin, humanized, and related paths for Setx (human SETX). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Setx catalog models
2 Setx lines with QC documentation and technical support.
Looking for a Setx mouse model?
We have 2 Setx models available — including Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Setx Mouse Model Types
A Setx knockout mouse has the Setx gene permanently inactivated, enabling loss of function studies. Setx knockin models carry a precisely inserted sequence at the Setx locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Setx organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Setx line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.