What Sf3b1 Knockout mouse models are available?

When Sf3b1 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Sf3b1 knockout embryonic lethal in mice?

It depends on background and allele design. Some Sf3b1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Sf3b1 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Sf3b1?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●1 Model Available

Sf3b1 Knockout mouse model

Name: Sf3b1-KO
Brand: ingenious targeting laboratory
SKU: KO 250116
Availability: PreOrder

Browse 1 Sf3b1 mouse model including knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.

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Why model Sf3b1

Splicing fidelity depends on Sf3b1, the mouse ortholog of human SF3B1, the largest subunit of the SF3b module of the U2 small nuclear ribonucleoprotein, built from twenty HEAT repeats that clamp the pre-messenger RNA branch point adenosine and stabilize U2 snRNA duplex formation during A complex assembly, with PHF5A and SF3B3 completing the pocket targeted by pladienolide and related modulators. Cancer-associated mutations are heterozygous, mutually exclusive missense changes, chiefly K700E in myelodysplastic syndrome with ring sideroblasts and in chronic lymphocytic leukemia, and R625 substitutions in uveal melanoma, acting as change of function by promoting cryptic 3 prime splice site selection and nonsense-mediated decay of transcripts such as Abcb7 and Map3k7. Consequently, conditional heterozygous hotspot knockins are the only faithful design, since homozygous mutant and null alleles are lethal, and induction with Mx1-cre or Vav1-cre reproduces dysplastic erythropoiesis. Match allele class to endpoint, whether mis-splicing catalogs, sideroblastic phenotype, or spliceosome modulator sensitivity.

What Sf3b1 mouse models are available?

ingenious targeting laboratory offers 1 distinct Sf3b1 (SF3B1) catalog mouse model, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
1 Ready Catalog Line	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Cryo or Live Dispatch Options

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Cryo or Live Dispatch Options

Sf3b1 model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
Request a quote
Humanized
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Transgenic / overexpression
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Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Sf3b1 allele types

Knockout, conditional, knockin, humanized, and related paths for Sf3b1 (human SF3B1). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

Browse Full Catalog

Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

Request a Quote Explore model generation services

Available Sf3b1 catalog models

1 Sf3b1 line with QC documentation and technical support.

Sf3b1-KO
Knockout
KO/CKO mice
sperm cryopreservationKO 250116
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Selected publications from ingenious targeting laboratory

Peer reviewed work involving Sf3b1 (SF3B1) from ITL supported projects.

GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignanciesBenbarche S, Pineda JMB, Galvis LB, Biswas J, Liu B, Wang E, Zhang Q, Hogg SJ, Lyttle K, Dahi A, Lewis AM, Sarchi M, Rahman J, Fox N, Ai Y, Mehta S, Garippa R, Ortiz-Pacheco J, Li Z, Monetti M, Stanley RF, Doulatov S, Bradley RK, Abdel-Wahab O. (2024). Mol Cell 84(10): 1886-1903

View all ITL publications

Looking for a Sf3b1 mouse model?

We have 1 Sf3b1 model available — including Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation