Conventional / global / constitutive KO
●2 Models Available
Shank3 Conditional Knockout, Knockout mouse models
Browse 2 Shank3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Shank3 conditional knockout mouse, Shank3 knockout mouse. Contact us for availability and fast turnaround.
Why model Shank3
Deletion of Shank3, the mouse ortholog of human SHANK3, is the principal genetic driver of Phelan-McDermid syndrome arising from 22q13.3 loss, and the gene encodes the most abundant SHANK scaffold in striatal and cortical postsynaptic densities, with ankyrin repeats, SH3, a PDZ domain binding GKAP/SAPAP, proline-rich Homer and cortactin sites, and a SAM domain that polymerizes the PSD lattice. Multiple intragenic promoters and extensive alternative splicing generate isoforms with distinct localization, which is why different exon-specific mouse lines produce divergent synaptic and behavioral phenotypes. Haploinsufficiency reduces AMPA and NMDA receptor content, impairs corticostriatal transmission, and produces repetitive grooming and social deficits. Allele planning must specify exact exons, choosing conditional null for reversibility studies, isoform-selective deletion matched to patient breakpoints, truncating knockins, or humanization for oligonucleotide and gene therapy testing. Partial redundancy with Shank1 and Shank2 argues for compound alleles when total scaffold capacity is the endpoint.
What Shank3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Shank3 (SHANK3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Shank3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Shank3 allele types
Knockout, conditional, knockin, humanized, and related paths for Shank3 (human SHANK3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Shank3 catalog models
2 Shank3 lines with QC documentation and technical support. Shank3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Shank3 mouse model?
We have 2 Shank3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Shank3 Mouse Model Types
A Shank3 knockout mouse has the Shank3 gene permanently inactivated, enabling loss of function studies. A Shank3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Shank3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Shank3 organized by modification type. Each URL is indexable and matches common search patterns.