Conventional / global / constitutive KO
●2 Models Available
Shc1 Conditional Knockout, Knockout mouse models
Browse 2 Shc1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Shc1 conditional knockout mouse, Shc1 knockout mouse. Contact us for availability and fast turnaround.
Why model Shc1
Three isoforms, p46, p52 and p66, arise from Shc1, the ortholog of human SHC1, through alternative translation initiation and promoter use; all share a phosphotyrosine-binding domain and an SH2 domain that engage NPXY motifs on activated receptor tyrosine kinases, plus a CH1 region whose Tyr239, Tyr240 and Tyr317 phosphorylation recruits GRB2 and SOS1 to load RAS and activate ERK. The p66 isoform is functionally distinct, carrying a CH2 extension whose Ser36 phosphorylation under oxidative stress promotes mitochondrial translocation, cytochrome c oxidation and hydrogen peroxide generation, linking the locus to oxidative stress resistance and lifespan. Because pan-locus deletion is embryonic lethal with cardiovascular defects, adult questions require conditional nulls, whereas isoform-selective p66 knockouts are viable and are the correct allele for aging and redox endpoints. The paralogs Shc2, Shc3 and Shc4 have restricted neural and muscle expression and do not broadly compensate, so tissue context should guide interpretation.
What Shc1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Shc1 (SHC1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Shc1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Shc1 allele types
Knockout, conditional, knockin, humanized, and related paths for Shc1 (human SHC1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Shc1 catalog models
2 Shc1 lines with QC documentation and technical support. Shc1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Shc1 mouse model?
We have 2 Shc1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Shc1 Mouse Model Types
A Shc1 knockout mouse has the Shc1 gene permanently inactivated, enabling loss of function studies. A Shc1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Shc1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Shc1 organized by modification type. Each URL is indexable and matches common search patterns.