Conventional / global / constitutive KO
●4 Models Available
Shh Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Shh mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Shh conditional knockout mouse, Shh knockin mouse, Shh knockout mouse. Request a quote within 24 hours.
Why model Shh
Shh is the mouse ortholog of human SHH and encodes Sonic hedgehog, which autoprocesses to attach cholesterol to the carboxy terminus of its signaling fragment and receives palmitate at Cys24 from HHAT, then depends on DISP1 and SCUBE2 for release before binding PTCH1 with the coreceptors CDON, BOC, and GAS1 to relieve SMO inhibition and shift ciliary GLI processing from GLI3 repressor toward activator forms. It patterns the ventral neural tube as floor plate signal and specifies digit identity from the zone of polarizing activity, and human mutations cause holoprosencephaly type 3 while pathway-activating PTCH1 and SMO lesions drive basal cell carcinoma and medulloblastoma. Nulls die with cyclopia and severe midline defects, so conditional deletion, holoprosencephaly missense knockins, and ZRS limb enhancer alleles each answer distinct questions. Ihh and Dhh overlap in gut and gonad, and Shh-Cre lines double as lineage drivers worth validating before use.
What Shh mouse models are available?
ingenious targeting laboratory offers 4 distinct Shh (SHH) catalog mouse models in the Hedgehog family, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Shh model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Shh allele types
Knockout, conditional, knockin, humanized, and related paths for Shh (human SHH). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Shh catalog models
4 Shh lines with QC documentation and technical support. Shh floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Shh mouse model?
We have 4 Shh models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Shh Mouse Model Types
A Shh knockout mouse has the Shh gene permanently inactivated, enabling loss of function studies. A Shh conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Shh, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Shh knockin models carry a precisely inserted sequence at the Shh locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Shh organized by modification type. Each URL is indexable and matches common search patterns.