Conventional / global / constitutive KO
●2 Models Available
Sirt1 Conditional Knockout, Xenograft-Applicable mouse models
Browse 2 Sirt1 mouse models including conditional knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Sirt1 conditional knockout mouse, Sirt1 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Sirt1
Sirt1, ortholog of human SIRT1, encodes an NAD+ dependent class III deacetylase whose catalytic core couples removal of acetyl groups to cleavage of NAD+ into nicotinamide and 2-O-acetyl-ADP-ribose, making activity a direct function of cellular NAD+ and a target of nicotinamide product inhibition. Substrates include p53 Lys382, FOXO factors, PGC-1 alpha, NF-kappaB p65 Lys310 and histone H4 Lys16, placing the enzyme at the intersection of stress response, mitochondrial biogenesis and inflammatory transcription, and it is allosterically activated by resveratrol-class compounds through an amino-terminal domain in a substrate-dependent manner. Germline deletion causes substantial perinatal lethality with developmental eye and cardiac defects on most backgrounds, favoring conditional nulls, while catalytically dead histidine to tyrosine knockins distinguish deacetylase activity from scaffolding. Because the allosteric activator site is itself the pharmacological question, activator-insensitive point knockins are often more informative than deletion when validating small molecule mechanism.
What Sirt1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Sirt1 (SIRT1) catalog mouse models, featuring conditional knockout and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Sirt1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Sirt1 allele types
Knockout, conditional, knockin, humanized, and related paths for Sirt1 (human SIRT1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Sirt1 catalog models
2 Sirt1 lines with QC documentation and technical support. Sirt1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Sirt1 mouse model?
We have 2 Sirt1 models in stock — including Conditional Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Sirt1 Mouse Model Types
A Sirt1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sirt1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Sirt1 organized by modification type. Each URL is indexable and matches common search patterns.