Conventional / global / constitutive KO
●3 Models Available
Sirpa Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Sirpa mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Sirpa conditional knockout mouse, Sirpa knockin mouse, Sirpa knockout mouse. Request a quote within 24 hours.
Why model Sirpa
Encoding signal regulatory protein alpha (CD172a), Sirpa is the mouse ortholog of human SIRPA and presents three extracellular immunoglobulin domains, of which the polymorphic IgV domain binds CD47, plus a cytoplasmic tail with two ITIMs that recruit SHP-1 and SHP-2 to block phagocytic cup maturation and myosin IIA accumulation in macrophages, neutrophils, and dendritic cells. This CD47 to SIRPA axis is the dominant myeloid checkpoint that tumors exploit, and it is under strong species constraint because mouse SIRPA binds human CD47 poorly, which is exactly why humanized IgV knockin strains greatly improve human hematopoietic engraftment in immunodeficient hosts. Design forks sharply: conditional nulls or cytoplasmic truncations test ITIM-dependent inhibition in a defined myeloid lineage, whereas full ectodomain humanization is mandatory for anti-SIRPA or CD47 blocking antibodies and xenograft work. Related Sirpb1 and Sirpg do not restore inhibitory signaling, so target red cell clearance, antibody-dependent phagocytosis, or engraftment endpoints.
What Sirpa mouse models are available?
ingenious targeting laboratory offers 3 distinct Sirpa (SIRPA) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Sirpa model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Sirpa allele types
Knockout, conditional, knockin, humanized, and related paths for Sirpa (human SIRPA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Sirpa catalog models
3 Sirpa lines with QC documentation and technical support. Sirpa floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Sirpa mouse model?
We have 3 Sirpa models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Sirpa Mouse Model Types
A Sirpa knockout mouse has the Sirpa gene permanently inactivated, enabling loss of function studies. A Sirpa conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sirpa, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Sirpa knockin models carry a precisely inserted sequence at the Sirpa locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Sirpa organized by modification type. Each URL is indexable and matches common search patterns.