Conventional / global / constitutive KO
●6 Models Available
Slc6a1 Conditional Knockout, Knockin, Knockout mouse models
Browse 6 Slc6a1 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Slc6a1 conditional knockout mouse, Slc6a1 knockin mouse, Slc6a1 knockout mouse. Request a quote within 24 hours.
Why model Slc6a1
GABA reuptake at cortical synapses is mediated by Slc6a1, the mouse ortholog of human SLC6A1, encoding GAT-1, a twelve-transmembrane sodium and chloride dependent symporter of the SLC6 family with the LeuT fold, expressed on GABAergic axon terminals and on astrocytes, where it terminates phasic inhibition and constrains ambient GABA and tonic conductance. It is the pharmacological target of tiagabine. Heterozygous SLC6A1 missense and truncating variants cause myoclonic atonic epilepsy, absence seizures, autism, and intellectual disability, and importantly many missense alleles act through misfolding and ER retention rather than pure haploinsufficiency, which strongly favors patient knockin over simple null when mechanism is the question. Slc6a1 knockout mice are viable with tremor, ataxia, elevated tonic inhibition, and altered seizure susceptibility. Use conditional alleles with neuronal versus astrocytic Cre drivers to separate the two GAT-1 pools, and humanized alleles when chaperone or oligonucleotide therapeutics are tested.
What Slc6a1 mouse models are available?
ingenious targeting laboratory offers 6 distinct Slc6a1 (SLC6A1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 6 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Slc6a1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Slc6a1 allele types
Knockout, conditional, knockin, humanized, and related paths for Slc6a1 (human SLC6A1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Slc6a1 catalog models
6 Slc6a1 lines with QC documentation and technical support. Slc6a1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Slc6a1-Flox
Conditional KnockoutKO/CKO mice
In production — inquireCKO 252340 - Order
Slc6a1-S295L
Knockinpoint mutantion mice
embryo cryopreservationKI 190014 - Order
Slc6a1-TRE
KnockinotherToolbox of Mice(Non-Cre, fluorescent)
embryo cryopreservationKI 200261 - Order
Slc6a1-KO(2)
KnockoutKO/CKO mice
embryo cryopreservationKO 210290 - Order
Slc6a1-KO(3)
KnockoutKO/CKO mice, disease model mice
sperm cryopreservationKO 210126 - Order
Slc6a1-KO
KnockoutKO/CKO mice, disease model mice
embryo cryopreservationKO 00002
Looking for a Slc6a1 mouse model?
We have 6 Slc6a1 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model6
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Slc6a1 Mouse Model Types
A Slc6a1 knockout mouse has the Slc6a1 gene permanently inactivated, enabling loss of function studies. A Slc6a1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Slc6a1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Slc6a1 knockin models carry a precisely inserted sequence at the Slc6a1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Slc6a1 organized by modification type. Each URL is indexable and matches common search patterns.