Conventional / global / constitutive KO
●7 Models Available
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LIVE · SPERM · EMBRYO · IN PRODUCTION
Slc6a1 Conditional Knockout, Knockin, Knockout mouse models
Browse 7 Slc6a1 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Slc6a1 conditional knockout mouse, Slc6a1 knockin mouse, Slc6a1 knockout mouse. Request a quote within 24 hours.
Why model Slc6a1
GABA reuptake at cortical synapses is mediated by Slc6a1, the mouse ortholog of human SLC6A1, encoding GAT-1, a twelve-transmembrane sodium and chloride dependent symporter of the SLC6 family with the LeuT fold, expressed on GABAergic axon terminals and on astrocytes, where it terminates phasic inhibition and constrains ambient GABA and tonic conductance. It is the pharmacological target of tiagabine. Heterozygous SLC6A1 missense and truncating variants cause myoclonic atonic epilepsy, absence seizures, autism, and intellectual disability, and importantly many missense alleles act through misfolding and ER retention rather than pure haploinsufficiency, which strongly favors patient knockin over simple null when mechanism is the question. Slc6a1 knockout mice are viable with tremor, ataxia, elevated tonic inhibition, and altered seizure susceptibility. Use conditional alleles with neuronal versus astrocytic Cre drivers to separate the two GAT-1 pools, and humanized alleles when chaperone or oligonucleotide therapeutics are tested.
What Slc6a1 mouse models are available?
ingenious targeting laboratory offers 7 distinct Slc6a1 (SLC6A1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 7 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Slc6a1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Slc6a1 allele types
Knockout, conditional, knockin, humanized, and related paths for Slc6a1 (human SLC6A1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Slc6a1 catalog models
7 Slc6a1 lines with QC documentation and technical support. Slc6a1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Slc6a1-Flox
CKOCKO
These mice carry loxP sites flanking exon 2-5 of Slc6a1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Slc6a1 gene.
In production — inquireCKO 252340 - Order
Slc6a1-TRE
KIOther Toolbox (non-Cre, non-Fluorescent)
TRE expression cassette was knocked into the intron1 of Slc6a1 gene.
Embryo CryopreservedKI 200261 - Order
Slc6a1-S295L
KIPoint Mutation
These mice carry a p.S295L mutation in Slc6a1 gene .
LiveKI 190014 - Order
Slc6a1-KO(2)
KOKO
Slc6a1-KO(2) mice(Stock No.KO 210290）carry a knockout allele derived from the targeted deletion of exon 6. While Slc6a1-KO mice (Stock No.KO 00002）carrying the exon 2-3 deletion. Slc6a1-KO(3) mice(Stock No.KO 210126） carrying the exon 7 deletion.
Embryo CryopreservedKO 210290 - Order
Slc6a1-KO
KOKO, Disease Model
Slc6a1-KO mice(Stock No.KO 00002）carry a knockout allele derived from the targeted deletion of exon 2-3. While Slc6a1-KO(2) mice (Stock No.KO 210290）carrying the exon 6 deletion. Slc6a1-KO(3) mice(Stock No.KO 210126） carrying the exon 7 deletion.
Embryo CryopreservedKO 00002 - Order
Slc6a1-KO(3)
KOKO, Disease Model
Slc6a1-KO(3) mice(Stock No.KO 210126）carry a knockout allele derived from the targeted deletion of exon 7. While Slc6a1-KO mice (Stock No.KO 00002）carrying the exon 2-3 deletion. Slc6a1-KO(2) mice(Stock No.KO 210290） carrying the exon 6 deletion.
Sperm CryopreservedKO 210126 - Order
Slc6a1-KO(4)
KOKO
The exon 2-5 of Slc6a1 gene was deleted to generate Slc6a1 knockout mouse.
LiveKO 254039
Looking for a Slc6a1 mouse model?
We have 7 Slc6a1 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
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Quote Turnaround
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QC Documentation
About Slc6a1 Mouse Model Types
A Slc6a1 knockout mouse has the Slc6a1 gene permanently inactivated, enabling loss of function studies. A Slc6a1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Slc6a1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Slc6a1 knockin models carry a precisely inserted sequence at the Slc6a1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Slc6a1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Slc6a1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.