Conventional / global / constitutive KO
●2 Models Available
Snca Conditional Knockout, Knockout mouse models
Browse 2 Snca mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Snca conditional knockout mouse, Snca knockout mouse. Request a quote within 24 hours.
Why model Snca
Alpha-synuclein, encoded by mouse Snca and orthologous to human SNCA, is a 140 residue intrinsically disordered presynaptic protein with an amphipathic N-terminal region of imperfect KTKEGV repeats that folds into a helix on acidic membranes, a hydrophobic NAC segment driving amyloid assembly, and an acidic C-terminal tail mediating calcium and chaperone interactions. Physiologically it chaperones SNARE complex assembly through VAMP2 binding and modulates synaptic vesicle clustering; pathologically it forms Lewy body fibrils and propagates in a prion-like manner. Dominant missense alleles A53T, A30P, and E46K plus SNCA locus duplication and triplication cause Parkinson disease, establishing dosage as a driver. Critically, mouse Snca natively encodes threonine at position 53, so humanized knockin alleles are the correct choice for aggregation and antibody studies rather than relying on murine sequence. Redundancy with Sncb and Sncg is real, so pair conditional nulls with compound alleles when synaptic function is the endpoint.
What Snca mouse models are available?
ingenious targeting laboratory offers 2 distinct Snca (SNCA) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Snca model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Snca allele types
Knockout, conditional, knockin, humanized, and related paths for Snca (human SNCA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Snca catalog models
2 Snca lines with QC documentation and technical support. Snca floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Snca mouse model?
We have 2 Snca models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Snca Mouse Model Types
A Snca knockout mouse has the Snca gene permanently inactivated, enabling loss of function studies. A Snca conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Snca, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Snca organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Snca.