Conventional / global / constitutive KO
●1 Model Available
Sos1 Conditional Knockout mouse model
Browse 1 Sos1 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Sos1
Sos1, ortholog of human SOS1, encodes the principal guanine nucleotide exchange factor for RAS, using a CDC25 homology domain and an adjacent REM domain to catalyze nucleotide release, an allosteric RAS-GTP binding site that generates positive feedback, and DH and PH domains that confer RAC exchange activity. Basal output is restrained by an amino-terminal histone fold and a carboxy-terminal proline-rich tail that binds GRB2 SH3 domains, coupling exchange to receptor tyrosine kinase phosphotyrosine. Germline gain-of-function substitutions relieve that autoinhibition and cause Noonan syndrome, so patient knockins address developmental and cardiac endpoints, while conditional nulls test the requirement for wild-type RAS loading in tumors treated with SOS1 inhibitors or with KRAS G12C inhibitors that depend on nucleotide cycling. Constitutive deletion is embryonic lethal from placental failure, whereas the paralog Sos2 supports adult viability and compensates partially, making compound Sos1 and Sos2 alleles the informative dependency design.
What Sos1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Sos1 (SOS1) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Sos1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Sos1 allele types
Knockout, conditional, knockin, humanized, and related paths for Sos1 (human SOS1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Sos1 catalog models
1 Sos1 line with QC documentation and technical support. Sos1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Sos1-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 2100737
Looking for a Sos1 mouse model?
We have 1 Sos1 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Sos1 Mouse Model Types
A Sos1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sos1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Sos1 organized by modification type. Each URL is indexable and matches common search patterns.