Conventional / global / constitutive KO
●2 Models Available
Srebf1 Conditional Knockout, Knockout mouse models
Browse 2 Srebf1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Srebf1 conditional knockout mouse, Srebf1 knockout mouse. Request a quote within 24 hours.
Why model Srebf1
Srebf1, ortholog of human SREBF1, encodes membrane-bound basic helix-loop-helix leucine zipper transcription factors, SREBP-1a and the liver and adipose enriched SREBP-1c, produced from alternative promoters and first exons. Both are synthesized as endoplasmic reticulum precursors held by SCAP and, when sterols are abundant, retained through INSIG binding; sterol depletion permits COPII transport to the Golgi, sequential cleavage by S1P and S2P, and release of the nuclear form that occupies sterol response elements to drive Acaca, Fasn, Scd1 and Elovl6. SREBP-1c is additionally induced by insulin through AKT and by LXR agonism, making the locus the transcriptional hub of de novo lipogenesis. Hepatocyte or adipocyte conditional nulls address tissue-autonomous lipogenesis, while nuclear-form transgenes test sufficiency without processing control. Srebf2 partially substitutes at shared promoters, so measure both nuclear forms before attributing altered fatty acid synthesis to Srebf1 alone.
What Srebf1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Srebf1 (SREBF1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Srebf1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Srebf1 allele types
Knockout, conditional, knockin, humanized, and related paths for Srebf1 (human SREBF1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Srebf1 catalog models
2 Srebf1 lines with QC documentation and technical support. Srebf1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Srebf1 mouse model?
We have 2 Srebf1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Srebf1 Mouse Model Types
A Srebf1 knockout mouse has the Srebf1 gene permanently inactivated, enabling loss of function studies. A Srebf1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Srebf1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Srebf1 organized by modification type. Each URL is indexable and matches common search patterns.