Conventional / global / constitutive KO
●2 Models Available
Syngap1 Conditional Knockout, Knockin mouse models
Browse 2 Syngap1 mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Syngap1 conditional knockout mouse, Syngap1 knockin mouse. Request a quote within 24 hours.
Why model Syngap1
Synaptic Ras GTPase-activating protein, encoded by mouse Syngap1 and orthologous to human SYNGAP1, is among the most abundant postsynaptic density proteins, containing a pleckstrin homology domain, a C2 domain, a RasGAP catalytic domain active on both Ras and Rap, and a C-terminal PDZ-binding motif anchoring it to PSD-95. By restraining Ras-ERK signaling it limits AMPA receptor insertion and spine maturation, and its rapid NMDA receptor-driven phosphorylation and dispersal from the density is a required step in long-term potentiation. Alternative C-terminal isoforms alpha1, alpha2, beta, and gamma exert opposing effects on synaptic strength. Heterozygous de novo truncating variants cause SYNGAP1-related intellectual disability with epilepsy and autism, and homozygous null mice die within days of birth, so heterozygous or conditional alleles are mandatory. Choose conditional null for reversibility and cell-autonomy studies with excitatory or interneuron Cre drivers, isoform-specific alleles for the C-terminal question, and humanization for oligonucleotide upregulation testing.
What Syngap1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Syngap1 (SYNGAP1) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Syngap1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Syngap1 allele types
Knockout, conditional, knockin, humanized, and related paths for Syngap1 (human SYNGAP1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Syngap1 catalog models
2 Syngap1 lines with QC documentation and technical support. Syngap1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Syngap1 mouse model?
We have 2 Syngap1 models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Syngap1 Mouse Model Types
A Syngap1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Syngap1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Syngap1 knockin models carry a precisely inserted sequence at the Syngap1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Syngap1 organized by modification type. Each URL is indexable and matches common search patterns.