Conventional / global / constitutive KO
●3 Models Available
Tardbp Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Tardbp mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Tardbp conditional knockout mouse, Tardbp knockin mouse, Tardbp knockout mouse. Contact us for availability and fast turnaround.
Why model Tardbp
Nuclear TDP-43, encoded by mouse Tardbp and orthologous to human TARDBP, is a heterogeneous nuclear ribonucleoprotein with two RRM domains binding UG-rich RNA and a C-terminal glycine-rich prion-like low complexity domain mediating phase separation and protein interaction. It represses cryptic exon inclusion in transcripts such as STMN2 and UNC13A, regulates splicing and mRNA stability, and autoregulates its own abundance by binding its 3-prime untranslated region. In ALS and frontotemporal lobar degeneration, TDP-43 mislocalizes from the nucleus and forms hyperphosphorylated, ubiquitinated cytoplasmic inclusions, and rare dominant mutations cluster in the low complexity domain, including M337V, A315T, and Q331K. Because Tardbp null embryos die around implantation and overexpression is independently toxic, endogenous locus knockins and conditional alleles are strongly preferred over transgenes. Match design to question, using nuclear localization signal mutants for mislocalization, patient missense knockins for aggregation, and humanized alleles when cryptic exon readouts require human sequence context.
What Tardbp mouse models are available?
ingenious targeting laboratory offers 3 distinct Tardbp (TDP43) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tardbp model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tardbp allele types
Knockout, conditional, knockin, humanized, and related paths for Tardbp (human TARDBP). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tardbp catalog models
3 Tardbp lines with QC documentation and technical support. Tardbp floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Tardbp (TARDBP) from ITL supported projects.
- NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.Gleixner AM, Verdone BM, Otte CG, Anderson EN, Ramesh N, Shapiro OR, Gale JR, Mauna JC, Mann JR, Copley KE, Daley EL, Ortega JA, Cicardi ME, Kiskinis E, Kofler J, Pandey UB, Trotti D, Donnelly CJ. (2022). Nat Commun 13(1): 3380
Looking for a Tardbp mouse model?
We have 3 Tardbp models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tardbp Mouse Model Types
A Tardbp knockout mouse has the Tardbp gene permanently inactivated, enabling loss of function studies. A Tardbp conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tardbp, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Tardbp knockin models carry a precisely inserted sequence at the Tardbp locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Tardbp organized by modification type. Each URL is indexable and matches common search patterns.