Conventional / global / constitutive KO
●3 Models Available
Tbk1 Conditional Knockout, Knockout mouse models
Browse 3 Tbk1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tbk1 conditional knockout mouse, Tbk1 knockout mouse. Request a quote within 24 hours.
Why model Tbk1
Tbk1, the mouse ortholog of human TBK1, encodes a serine threonine kinase of the IKK family with kinase, ubiquitin-like, and scaffold dimerization domains that phosphorylates STING at Ser366 and IRF3 at Ser396 to drive type I interferon transcription downstream of cGAS, RIG-I through MAVS, and TLR3 through TRIF, and separately phosphorylates the autophagy receptors OPTN and SQSTM1 to license selective mitophagy and xenophagy. Human haploinsufficiency and loss of function mutations cause amyotrophic lateral sclerosis and frontotemporal dementia, while excess interferon output underlies its interest in autoinflammation. Germline nulls die at midgestation from TNF-dependent hepatic apoptosis, a lethality rescued on a Tnfrsf1a-null background, so practical alleles include kinase-dead knockins, phosphosite mutants, conditional deletion, and truncating patient variants. Ikbke partially covers interferon induction in myeloid cells, so compound genetics may be required, and allele choice should track interferon output, mitophagy flux, or motor neuron phenotypes.
What Tbk1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tbk1 (TBK1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tbk1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tbk1 allele types
Knockout, conditional, knockin, humanized, and related paths for Tbk1 (human TBK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tbk1 catalog models
3 Tbk1 lines with QC documentation and technical support. Tbk1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tbk1 mouse model?
We have 3 Tbk1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tbk1 Mouse Model Types
A Tbk1 knockout mouse has the Tbk1 gene permanently inactivated, enabling loss of function studies. A Tbk1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tbk1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tbk1 organized by modification type. Each URL is indexable and matches common search patterns.