Conventional / global / constitutive KO
●4 Models Available
Tet2 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Tet2 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tet2 conditional knockout mouse, Tet2 knockin mouse, Tet2 knockout mouse. Request a quote within 24 hours.
Why model Tet2
Tet2 is the mouse ortholog of human TET2 and encodes an iron and 2-oxoglutarate dependent dioxygenase that oxidizes 5-methylcytosine to 5-hydroxymethylcytosine and further products, initiating active and passive demethylation at enhancers; unlike Tet1 and Tet3 it lacks a CXXC domain and instead relies on partners such as IDAX, WT1, and EBF1 for locus targeting. Truncating and catalytic domain missense mutations make TET2 one of the most frequent drivers of clonal hematopoiesis and of myelodysplastic syndrome, chronic myelomonocytic leukemia, and angioimmunoblastic T cell lymphoma, and its activity is phenocopied by IDH1 or IDH2 neomorphic mutations through 2-hydroxyglutarate inhibition while being stimulated by ascorbate. Germline nulls are viable with progressive hematopoietic stem cell expansion, myeloid bias, and long tumor latency, so conditional nulls with Vav1-cre or Mx1-cre plus a cooperating Flt3 internal tandem duplication or Jak2 V617F allele sharpen the phenotype. Paralogs Tet1 and Tet3 partially buffer hydroxymethylation, making compound conditional alleles worthwhile.
What Tet2 mouse models are available?
ingenious targeting laboratory offers 4 distinct Tet2 (TET2) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tet2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tet2 allele types
Knockout, conditional, knockin, humanized, and related paths for Tet2 (human TET2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tet2 catalog models
4 Tet2 lines with QC documentation and technical support. Tet2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Tet2 (TET2) from ITL supported projects.
- Epigenetic modulation of β cells by interferon-α via PNPT1/mir-26a/TET2 triggers autoimmune diabetesStefan-Lifshitz M, Karakose E, Cui L, Ettela A, Yi Z, Zhang W, Tomer Y. (2019). JCI Insight4(5). pii: 126663
Looking for a Tet2 mouse model?
We have 4 Tet2 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tet2 Mouse Model Types
A Tet2 knockout mouse has the Tet2 gene permanently inactivated, enabling loss of function studies. A Tet2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tet2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Tet2 knockin models carry a precisely inserted sequence at the Tet2 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Tet2 organized by modification type. Each URL is indexable and matches common search patterns.