Conventional / global / constitutive KO
●2 Models Available
Ticam1 Knockout mouse models
Browse 2 Ticam1 mouse models including knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Ticam1
Encoding the adaptor TRIF, Ticam1 is the mouse ortholog of human TICAM1 and supplies the MyD88-independent arm of Toll-like receptor signaling, using a central TIR domain to engage TLR3 directly and TLR4 through TRAM (Ticam2) after endosomal internalization, an N-terminal region that recruits TRAF3 with the TBK1 and IKK epsilon complex for IRF3-driven type I interferon, and a C-terminal RHIM that binds RIPK1 and RIPK3 to trigger NF-kB, apoptosis, or necroptosis depending on caspase-8 availability. The classic Lps2 frameshift allele established that TRIF loss abolishes poly(I:C) responses and the late-phase LPS interferon response while sparing early MyD88 signaling. Nulls are viable, so germline deletion is tractable, whereas RHIM or TRAF-binding knockins separate interferon induction from death signaling and Myd88 compound alleles are needed because both adaptors serve TLR4. Fit alleles to interferon beta induction, endotoxin tolerance, or virus-induced tissue damage endpoints.
What Ticam1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Ticam1 (TICAM1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ticam1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ticam1 allele types
Knockout, conditional, knockin, humanized, and related paths for Ticam1 (human TICAM1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Ticam1 mouse model?
We have 2 Ticam1 models in stock — including Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ticam1 Mouse Model Types
A Ticam1 knockout mouse has the Ticam1 gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for Ticam1 organized by modification type. Each URL is indexable and matches common search patterns.