Conventional / global / constitutive KO
●2 Models Available
Tnfrsf1a Conditional Knockout, Knockout mouse models
Browse 2 Tnfrsf1a mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tnfrsf1a conditional knockout mouse, Tnfrsf1a knockout mouse. Request a quote within 24 hours.
Why model Tnfrsf1a
Tnfrsf1a, the mouse ortholog of human TNFRSF1A, encodes TNFR1 (p55), a receptor whose four cysteine-rich extracellular domains bind soluble and membrane TNF and whose cytoplasmic death domain nucleates complex I through TRADD, RIPK1, TRAF2, and cIAP1 and cIAP2, where LUBAC-generated linear ubiquitin recruits TAB and IKK complexes for NF-kB and MAPK output. When ubiquitin editing fails or translation is blocked, RIPK1 disengages into cytosolic complex II, producing caspase-8 apoptosis or RIPK3 and MLKL necroptosis, while ADAM17 shedding generates soluble receptor that buffers ligand, and human cysteine-altering mutations cause TNF receptor associated periodic syndrome through misfolding and retention. Nulls are viable and resistant to endotoxin lethality, so germline deletion is a workhorse, conditional alleles assign requirement to intestinal epithelium, endothelium, or neurons, patient point knockins model autoinflammation, and humanization is needed because etanercept and infliximab engage human ligand. Match alleles to shock, colitis, or demyelination endpoints.
What Tnfrsf1a mouse models are available?
ingenious targeting laboratory offers 2 distinct Tnfrsf1a (TNFRSF1A) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tnfrsf1a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tnfrsf1a allele types
Knockout, conditional, knockin, humanized, and related paths for Tnfrsf1a (human TNFRSF1A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tnfrsf1a catalog models
2 Tnfrsf1a lines with QC documentation and technical support. Tnfrsf1a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tnfrsf1a mouse model?
We have 2 Tnfrsf1a models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tnfrsf1a Mouse Model Types
A Tnfrsf1a knockout mouse has the Tnfrsf1a gene permanently inactivated, enabling loss of function studies. A Tnfrsf1a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tnfrsf1a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tnfrsf1a organized by modification type. Each URL is indexable and matches common search patterns.