Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
LIVE · DEVELOPING
Tsc1 Conditional Knockout, Knockout mouse models
Browse 2 Tsc1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tsc1 conditional knockout mouse, Tsc1 knockout mouse. Request a quote within 24 hours.
Why model Tsc1
Hamartin, the product of Tsc1 (mouse ortholog of human TSC1), stabilizes tuberin and TBC1D7 within the TSC complex, the RHEB-directed GTPase-activating module that clamps mTORC1 at the lysosomal surface; growth factor signaling through AKT, ERK, and RSK phosphorylates the complex to relieve this restraint, whereas AMPK reinforces it under energy stress. Loss-of-function alleles produce tuberous sclerosis complex with cortical tubers, subependymal giant cell astrocytoma, angiomyolipoma, and pulmonary lymphangioleiomyomatosis, all driven by constitutive S6K1 and 4E-BP1 phosphorylation. Since homozygous deletion is embryonic lethal from liver hypoplasia and neural tube defects, mechanistic work depends on floxed exons combined with Nestin, Emx1, Synapsin, or Pax8 Cre, while heterozygotes serve tumor predisposition studies. Critically, Tsc1 and Tsc2 are obligate partners rather than redundant paralogs, so hamartin loss destabilizes tuberin and no compound genetics can rescue; align allele class with rapamycin sensitivity or seizure and lesion endpoints.
What Tsc1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Tsc1 (TSC1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tsc1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tsc1 allele types
Knockout, conditional, knockin, humanized, and related paths for Tsc1 (human TSC1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tsc1 catalog models
2 Tsc1 lines with QC documentation and technical support. Tsc1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Tsc1-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 17-18 of Tsc1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tsc1 gene.
LiveCKO 200231 - Order
Tsc1-KO
KOKO
The exon17-18 of Tsc1 gene was deleted to generate Tsc1 knockout mouse.
In DevelopmentKO 262929
Looking for a Tsc1 mouse model?
We have 2 Tsc1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tsc1 Mouse Model Types
A Tsc1 knockout mouse has the Tsc1 gene permanently inactivated, enabling loss of function studies. A Tsc1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tsc1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tsc1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Tsc1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.