Conventional / global / constitutive KO
●3 Models Available
Tsc2 Conditional Knockout, Knockout mouse models
Browse 3 Tsc2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tsc2 conditional knockout mouse, Tsc2 knockout mouse. Request a quote within 24 hours.
Why model Tsc2
Tuberin, encoded by Tsc2 (mouse ortholog of human TSC2), supplies the catalytic GAP domain that hydrolyzes RHEB-GTP on lysosomal membranes, and its loss produces ligand-independent mTORC1 activity, sustained S6K1 and 4E-BP1 phosphorylation, and secondary IRS1 degradation that dampens upstream AKT. Patient alleles range from truncations to GAP-domain missense substitutions and to variants that merely destabilize the hamartin interaction, which is why a disease-specific knockin answers a different question than a conditional null: the former resolves catalytic versus structural failure and genotype-phenotype severity, the latter defines lineage requirements. Homozygous deletion is embryonic lethal by mid-gestation, and heterozygotes develop renal cystadenoma and hepatic hemangioma, echoing the Eker rat. No paralog substitutes for tuberin, since TSC1 and TBC1D7 are stoichiometric partners rather than backups, so pair floxed alleles with kidney, brain, or smooth muscle Cre drivers and read out mTORC1 flux, lesion burden, and rapalog or ATP-competitive inhibitor response.
What Tsc2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tsc2 (TSC2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tsc2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tsc2 allele types
Knockout, conditional, knockin, humanized, and related paths for Tsc2 (human TSC2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tsc2 catalog models
3 Tsc2 lines with QC documentation and technical support. Tsc2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tsc2 mouse model?
We have 3 Tsc2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tsc2 Mouse Model Types
A Tsc2 knockout mouse has the Tsc2 gene permanently inactivated, enabling loss of function studies. A Tsc2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tsc2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tsc2 organized by modification type. Each URL is indexable and matches common search patterns.