Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM · DEVELOPING
Tsc2 Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 4 Tsc2 mouse models including conditional knockout, knockout, xenograft-applicable variants from ingenious targeting laboratory. Available as Tsc2 conditional knockout mouse, Tsc2 knockout mouse, Tsc2 xenograft-applicable mouse. Contact us for availability and fast turnaround.
Why model Tsc2
Tuberin, encoded by Tsc2 (mouse ortholog of human TSC2), supplies the catalytic GAP domain that hydrolyzes RHEB-GTP on lysosomal membranes, and its loss produces ligand-independent mTORC1 activity, sustained S6K1 and 4E-BP1 phosphorylation, and secondary IRS1 degradation that dampens upstream AKT. Patient alleles range from truncations to GAP-domain missense substitutions and to variants that merely destabilize the hamartin interaction, which is why a disease-specific knockin answers a different question than a conditional null: the former resolves catalytic versus structural failure and genotype-phenotype severity, the latter defines lineage requirements. Homozygous deletion is embryonic lethal by mid-gestation, and heterozygotes develop renal cystadenoma and hepatic hemangioma, echoing the Eker rat. No paralog substitutes for tuberin, since TSC1 and TBC1D7 are stoichiometric partners rather than backups, so pair floxed alleles with kidney, brain, or smooth muscle Cre drivers and read out mTORC1 flux, lesion burden, and rapalog or ATP-competitive inhibitor response.
What Tsc2 mouse models are available?
ingenious targeting laboratory offers 4 distinct Tsc2 (TSC2) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Tsc2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tsc2 allele types
Knockout, conditional, knockin, humanized, and related paths for Tsc2 (human TSC2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tsc2 catalog models
4 Tsc2 lines with QC documentation and technical support. Tsc2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Tsc2-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 3-5 of Tsc2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tsc2 gene.
Sperm CryopreservedCKO 2102032 - Order
Tsc2-Flox(2)
CKOCKO
These strains carry loxP sites flanking exon 4-5 of Tsc2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tsc2 gene.
Sperm CryopreservedCKO 241018 - Order
Tsc2-KO
KOKO
The exon 4-5 of Tsc2 gene was deleted to generate Tsc2 knockout mouse.
Sperm CryopreservedKO 251011 - Order
Tsc2-Flox/R26-CreERT2
XACKO, Cre/Dre Toolbox
The Tsc2-Flox (CKO 2102032) was crossed with R26-CreERT2(KI 200041) to generate Tsc2-Flox/R26-CreERT2 mice.
In DevelopmentXA 253917
Looking for a Tsc2 mouse model?
We have 4 Tsc2 models available — including Conditional Knockout, Knockout, Xenograft-Applicable types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tsc2 Mouse Model Types
A Tsc2 knockout mouse has the Tsc2 gene permanently inactivated, enabling loss of function studies. A Tsc2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tsc2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tsc2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Tsc2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.