Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
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Vapb Conditional Knockout, Knockout mouse models
Browse 2 Vapb mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Vapb conditional knockout mouse, Vapb knockout mouse. Request a quote within 24 hours.
Why model Vapb
Endoplasmic reticulum membrane contact sites are organized in part by Vapb, the mouse ortholog of human VAPB, encoding a tail-anchored ER protein whose cytosolic major sperm protein domain binds FFAT motifs in lipid transfer and tethering partners such as OSBP, ORP family proteins, STARD3, and PTPIP51, coupling the ER to mitochondria, endosomes, and the plasma membrane for sterol, phosphatidylserine, and calcium exchange. The dominant P56S mutation misfolds that domain, forming insoluble ER inclusions that sequester wild type VAPB and VAPA, causing ALS8 and late-onset spinal muscular atrophy, while a cleaved fragment can be secreted and act on Eph receptors. Model design should separate P56S knockin at the endogenous locus, which captures the dominant aggregation mechanism, from conditional null, which tests contact site function; note that Vapb nulls are viable with only mild late deficits. Genuine redundancy with Vapa argues for compound alleles when lipid transfer is the endpoint.
What Vapb mouse models are available?
ingenious targeting laboratory offers 2 distinct Vapb (VAPB) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Vapb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Vapb allele types
Knockout, conditional, knockin, humanized, and related paths for Vapb (human VAPB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Vapb catalog models
2 Vapb lines with QC documentation and technical support. Vapb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Vapb-Flox
CKOCKO
These mice carry loxP sites flanking exon3 of Vapb gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Vapb gene.
In DevelopmentCKO 262927 - Order
Vapb-KO
KOKO
The exon 3 of Vapb gene was deleted to generate Vapb knockout mouse.
LiveKO 241164
Looking for a Vapb mouse model?
We have 2 Vapb models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Vapb Mouse Model Types
A Vapb knockout mouse has the Vapb gene permanently inactivated, enabling loss of function studies. A Vapb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Vapb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Vapb organized by modification type. Each URL is indexable and matches common search patterns.
Related Gene Targets
Breed this line with ingenious targeting laboratory
Send the Vapb line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.