Conventional / global / constitutive KO
●3 Models Available
Vhl Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 3 Vhl mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Vhl conditional knockout mouse, Vhl knockout mouse, Vhl xenograft-applicable mouse. Request a quote within 24 hours.
Why model Vhl
Vhl encodes the mouse ortholog of human VHL, the substrate recognition subunit of a cullin 2 RING E3 ubiquitin ligase that assembles with elongin B, elongin C, CUL2, and RBX1 and binds hydroxylated prolines in the oxygen-dependent degradation domains of HIF1A and HIF2A after prolyl hydroxylase modification, thereby coupling oxygen and 2-oxoglutarate availability to hypoxia inducible factor destruction. Biallelic inactivation, usually 3p25 deletion plus a truncating or missense hit, initiates clear cell renal carcinoma and drives von Hippel-Lindau disease with hemangioblastoma, pheochromocytoma, and pancreatic neuroendocrine tumors, with clear genotype specificity since type 2C alleles retain HIF regulation while losing other functions. Germline nulls die in midgestation from placental vasculogenesis failure, so conditional nulls with Pax8-cre or Ksp-cadherin-cre are standard, generally combined with Pbrm1, Bap1, or Setd2 deletion because Vhl loss alone rarely produces carcinoma in mouse kidney. Choose nulls for HIF2A dependence and belzutifan response, missense knockins for genotype-phenotype dissection.
What Vhl mouse models are available?
ingenious targeting laboratory offers 3 distinct Vhl (VHL) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Vhl model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Vhl allele types
Knockout, conditional, knockin, humanized, and related paths for Vhl (human VHL). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Vhl catalog models
3 Vhl lines with QC documentation and technical support. Vhl floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Vhl mouse model?
We have 3 Vhl models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Vhl Mouse Model Types
A Vhl knockout mouse has the Vhl gene permanently inactivated, enabling loss of function studies. A Vhl conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Vhl, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Vhl organized by modification type. Each URL is indexable and matches common search patterns.