Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
IN PRODUCTION
Vps35 Knockout mouse model
Browse 1 Vps35 mouse model including knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Vps35
Retromer cargo selection depends on Vps35, the mouse ortholog of human VPS35, encoding the alpha-solenoid scaffold that binds VPS26 and VPS29 to form the trimeric cargo recognition complex, which associates with sorting nexins and the WASH complex to retrieve transmembrane cargo, including the cation-independent mannose 6-phosphate receptor, GLUT1, sortilin, and DMT1, from endosomes to the trans-Golgi network and cell surface. The dominant D620N mutation causes late-onset autosomal dominant Parkinson disease PARK17 by impairing WASH complex binding, disrupting endosomal actin dynamics and cargo trafficking, and elevating LRRK2 kinase activity, placing retromer directly upstream of established parkinsonian signaling. Since constitutive Vps35 loss is embryonic lethal, useful designs are the D620N knockin at the endogenous locus for the dominant mechanism, conditional null for retromer collapse in dopaminergic neurons or microglia, and heterozygous null for dosage sensitivity. Match allele class to LRRK2 substrate phosphorylation, cargo mislocalization, or nigrostriatal integrity endpoints.
What Vps35 mouse models are available?
ingenious targeting laboratory offers 1 distinct Vps35 (VPS35) catalog mouse model, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Vps35 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Vps35 allele types
Knockout, conditional, knockin, humanized, and related paths for Vps35 (human VPS35). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Vps35 catalog models
1 Vps35 line with QC documentation and technical support.
- Order
Vps35-KO
KOKO
The exon3-5 of Vps35 gene was deleted to generate Vps35 knockout mouse.
In production — inquireKO 262329
Looking for a Vps35 mouse model?
We have 1 Vps35 model in stock — including Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Vps35 Mouse Model Types
A Vps35 knockout mouse has the Vps35 gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for Vps35 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Vps35 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.