Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · EMBRYO · DEVELOPING
Zbtb16 Conditional Knockout, Knockout mouse models
Browse 3 Zbtb16 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Zbtb16 conditional knockout mouse, Zbtb16 knockout mouse. Request a quote within 24 hours.
Why model Zbtb16
Zbtb16 is the mouse ortholog of human ZBTB16 (PLZF), a transcriptional repressor combining an N-terminal BTB or POZ dimerization domain with nine C-terminal C2H2 zinc fingers, which recruits NCOR1, SMRT, HDAC, and PRC1 components to target promoters and enforces spermatogonial stem cell self-renewal, innate effector programming of invariant natural killer T cells, and limb and axial skeletal patterning. In oncology it appears as the 5 prime partner of the t(11;17) ZBTB16-RARA fusion in a rare, all-trans retinoic acid resistant variant of acute promyelocytic leukemia, where the BTB domain drives constitutive oligomerization and corepressor recruitment that pharmacologic retinoid concentrations cannot dislodge. Germline nulls are viable, phenocopying the luxoid mutant with limb and vertebral defects and progressive loss of spermatogonial stem cells, so conditional nulls suit adult germline and immune endpoints, whereas inducible fusion knockins address differentiation therapy resistance. No close paralog substitutes for this BTB and zinc finger combination, so single-locus deletion is interpretable with a lineage-matched Cre.
What Zbtb16 mouse models are available?
ingenious targeting laboratory offers 3 distinct Zbtb16 (PLZF) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Zbtb16 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Zbtb16 allele types
Knockout, conditional, knockin, humanized, and related paths for Zbtb16 (human ZBTB16). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Zbtb16 catalog models
3 Zbtb16 lines with QC documentation and technical support. Zbtb16 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Zbtb16-Flox
CKOCKO
These mice carry loxP sites flanking exon 3 of Zbtb16 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Zbtb16 gene.
LiveCKO 253300 - Order
Zbtb16-KO(2)
KOKO
The exon 3 of Zbtb16 gene was deleted to generate Zbtb16 knockout mouse.
In DevelopmentKO 260543 - Order
Zbtb16-KO
KOKO
Exon 5-7 of Zbtb16 gene was deleted to generate Zbtb16 knockout mice.
F0 Embryo CryopreservedKO 191061
Looking for a Zbtb16 mouse model?
We have 3 Zbtb16 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Zbtb16 Mouse Model Types
A Zbtb16 knockout mouse has the Zbtb16 gene permanently inactivated, enabling loss of function studies. A Zbtb16 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Zbtb16, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Zbtb16 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Zbtb16 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.