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Recombination Systems & Tools

Dre-rox System (Alternate Recombinase)

An independent site-specific recombination platform derived from bacteriophage D6, using Dre recombinase to recognize rox sites for DNA rearrangements orthogonal to both Cre-lox and Flp-FRT.

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Overview

The Dre-rox system is an independent site-specific recombination platform derived from bacteriophage D6, using Dre recombinase to recognize rox sites for DNA rearrangements orthogonal to both Cre-lox and Flp-FRT.

Frequently Asked Questions

Does Dre recombine LoxP or FRT sites?

No. Dre acts exclusively on rox sites, ensuring complete orthogonality.

Why add Dre-rox to a Cre/Flp design?

To enable triple-layer logic or intersectional control without recombinase interference.

Related Services

Related Terms

Cre-lox System

A bacteriophage P1-derived site-specific recombination technology that utilizes Cre recombinase to mediate genomic modifications at engineered LoxP sequences. This technology underpins conditional gene engineering approaches in mammalian genetics.

Flp-FRT System

A yeast-derived site-specific recombination mechanism enabling targeted DNA excision, inversion, or integration through the interaction of Flp recombinase with FRT sites. It serves as an orthogonal complement to Cre-lox in mammalian genetics.

Inversion vs Excision (Recombination Outcomes)

The orientation of recombination sites determines genetic outcomes: direct repeats drive excision (deletion) of the intervening DNA, whereas inverted repeats cause inversion of the DNA segment.

More in Recombination Systems & Tools

Cre-lox SystemCre Driver Line (Tissue-Specific Cre)Floxed Gene / LoxP SiteLox-STOP-Lox (LSL) CassetteFlp-FRT System
Dominant NegativeView All TermsFloxed Gene / LoxP Site

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