Conventional / global / constitutive KO
●2 Models Available
Akt1 Knockin, Knockout mouse models
Browse 2 Akt1 mouse models including knockin, knockout variants from ingenious targeting laboratory. Available as Akt1 knockin mouse, Akt1 knockout mouse. Contact us for availability and fast turnaround.
Why model Akt1
As the dominant AGC kinase isoform in most tissues, Akt1 is the mouse ortholog of human AKT1 and encodes a PH domain kinase recruited to PIP3 generated by class I PI3K, activated by PDK1 phosphorylation of T308 in the activation loop and mTORC2 phosphorylation of S473 in the hydrophobic motif. Active AKT1 phosphorylates TSC2, PRAS40, GSK3 beta, BAD, and FOXO factors, coupling growth factor input to mTORC1 output, glycogen metabolism and apoptotic threshold. The recurrent E17K substitution in the PH domain locks the kinase at the membrane and drives Proteus syndrome and multiple carcinomas, so a conditional knockin of that codon addresses hyperactivation while a floxed null addresses requirement. Homozygous null mice are viable but growth restricted, and Akt2 and Akt3 compensate in muscle, liver and brain respectively, so isoform-specific conclusions demand compound alleles. Pair allele class to readout: null for dependency, E17K knockin for inhibitor pharmacodynamics.
What Akt1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Akt1 (AKT1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Akt1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Akt1 allele types
Knockout, conditional, knockin, humanized, and related paths for Akt1 (human AKT1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Akt1 mouse model?
We have 2 Akt1 models available — including Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Akt1 Mouse Model Types
A Akt1 knockout mouse has the Akt1 gene permanently inactivated, enabling loss of function studies. Akt1 knockin models carry a precisely inserted sequence at the Akt1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Akt1 organized by modification type. Each URL is indexable and matches common search patterns.