Conventional / global / constitutive KO
●2 Models Available
Atr Conditional Knockout, Knockout mouse models
Browse 2 Atr mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Atr conditional knockout mouse, Atr knockout mouse. Contact us for availability and fast turnaround.
Why model Atr
Distinct from ATM in trigger and kinetics, Atr is the mouse ortholog of human ATR and encodes the PIKK that responds to RPA coated single stranded DNA at stalled forks and resected ends, recruited through its obligate partner ATRIP and activated allosterically by TOPBP1 or ETAA1 to phosphorylate CHK1 at S317 and S345, RPA32 and the 9-1-1 clamp, thereby suppressing origin firing, stabilizing forks and enforcing the replication checkpoint. Complete loss is cell lethal and embryonic lethal, so hypomorphic Seckel syndrome knockins and conditional floxed alleles with inducible Cre are the only workable designs for studying replication stress in vivo. Acute conditional deletion in adult tissue produces stem cell attrition and progeroid features, giving a mechanistic readout for ATR inhibitor toxicity. Chek1 sits immediately downstream and is not redundant, so do not expect ATM to substitute. Select hypomorphs for chronic replication stress biology and conditional nulls for acute dependency and inhibitor mechanism-of-action work in ATM deficient or oncogene driven tumors.
What Atr mouse models are available?
ingenious targeting laboratory offers 2 distinct Atr (ATR) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Atr model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Atr allele types
Knockout, conditional, knockin, humanized, and related paths for Atr (human ATR). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Atr catalog models
2 Atr lines with QC documentation and technical support. Atr floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Atr (ATR) from ITL supported projects.
- Altered phosphorylation of the proteasome subunit Rpt6 has minimal impact on synaptic plasticity and learningScudder SL, Gonzales FR, Howell KK, Stein IS, Dozier LE, Anagnostaras SG, Zito K, Patrick GN. (2021). eNeuro 8(3): ENEURO.0073-20.2021
- Sox17 Regulates a Program of Oligodendrocyte Progenitor Cell Expansion and Differentiation during Development and RepairChew LJ, Ming X, McEllin B, Dupree J, Hong E, Catron M, Fauveau M, Nait-Oumesmar B, Gallo V. (2019). Cell Rep 29(10): 3173-3186.e7
- The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer DevelopmentGe C, Vilfranc CL, Che L, Pandita RK, Hambarde S, Andreassen PR, Niu L, Olowokure O, Shah S, Waltz SE, Zou L, Wang J, Pandita TK, Du C. (2019). Hepatology 69(6): 2608-2622
- Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophyGenabai NK, Kannan A, Ahmad S, Jiang X, Bhatia K, Gangwani L. (2017). Sci Rep 7: 8295
- Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices.Mierke CT, Fischer T, Puder S, Kunschmann T, Soetje B, Ziegler WH. (2017). Sci Rep7: 42780
Looking for a Atr mouse model?
We have 2 Atr models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Atr Mouse Model Types
A Atr knockout mouse has the Atr gene permanently inactivated, enabling loss of function studies. A Atr conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Atr, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Atr organized by modification type. Each URL is indexable and matches common search patterns.