Conventional / global / constitutive KO
●2 Models Available
Atrx Conditional Knockout, Knockout mouse models
Browse 2 Atrx mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Atrx conditional knockout mouse, Atrx knockout mouse. Contact us for availability and fast turnaround.
Why model Atrx
The X-linked Atrx locus, ortholog of human ATRX, encodes a SNF2-family ATPase whose ADD domain reads the combinatorial signal of unmethylated H3K4 with trimethylated H3K9, licensing recruitment to pericentromeric satellite repeats, telomeres, and imprinted loci. Acting as the obligate partner of DAXX, it deposits the replication-independent variant H3.3 into heterochromatin and resolves G-quadruplex structures during replication, so loss produces telomere dysfunction and the alternative lengthening of telomeres phenotype seen in pediatric glioblastoma, sarcoma, and pancreatic neuroendocrine tumors, alongside the developmental syndrome caused by hypomorphic missense alleles. Constitutive deletion is embryonic lethal, so exon-flanked conditional alleles combined with lineage Cre lines are standard, and hemizygous males versus heterozygous females demand explicit design decisions because of X inactivation mosaicism. No paralog substitutes for ADD-directed targeting. Select full conditional loss for telomere and genome instability endpoints, and point-mutant knockins when modeling syndromic missense biology.
What Atrx mouse models are available?
ingenious targeting laboratory offers 2 distinct Atrx (ATRX) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Atrx model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Atrx allele types
Knockout, conditional, knockin, humanized, and related paths for Atrx (human ATRX). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Atrx catalog models
2 Atrx lines with QC documentation and technical support. Atrx floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Atrx mouse model?
We have 2 Atrx models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Atrx Mouse Model Types
A Atrx knockout mouse has the Atrx gene permanently inactivated, enabling loss of function studies. A Atrx conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Atrx, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Atrx organized by modification type. Each URL is indexable and matches common search patterns.